Cayman Chemical

Antigen: human EP4 receptor N-terminal amino acids 1-22 Host: rabbit Cross Reactivity: (+) human and ovine EP4 receptors Application(s): WB Binding of PGE2 to the EP4 receptor causes an increase in intracellular cAMP and subsequent relaxation of smooth muscle. In addition to sequence differences,...

An analytical reference material categorized as a phytocannabinoid; a precursor in the biosynthesis of tetrahydrocannabinolic acid, cannabidiolic acid, and cannabichromenic acid; intended for research and forensic applications

A quorum sensing signal molecule that controls the expression of many virulence genes as a function of cell population density and can also chelate ferric iron at physiological pH.

A selective inhibitor of NLRP3, blocking the release of IL-1β in macrophages primed with LPS and activated with ATP or nigericin (IC₅₀ = 7.5 nM); active in vivo, blocking the production of IL-1β and enhancing survival in mouse models of multiple sclerosis and...

13,14-dihydro PGF1α is a potential metabolite of PGF1α. Its biological activity has not been reported. The corresponding compound in the E1 series (13,14-dihydro PGE1) retains biological activity similar to PGE1.

Antigen: human PAF receptor amino acids 260-269 Host: mouse, 11A4 clone 21 Cross Reactivity: (+) human, bovine, and porcine PAF receptor Application(s): FC, ICC; does not work for WB PAF is a biologically active phospholipid whose biological effects include activation of platelets, polymorphonuclear...

Potent HDAC6 inhibitor (IC50 = 15 nM) with 1,000-fold selectivity against all other HDAC isoforms (IC50s >16 μM), excluding HDAC8 (IC50 = 0.9 μM); induces α-tubulin hyperacetylation at 2.5 μM in primary cortical neuron cultures; displays dose-dependent neuronal protection of...

A partial agonist of the α4β2 neuronal nicotinic acetylcholine receptor (EC₅₀ = 2.3 µM); shows high selectivity for this receptor subclass relative to other nicotinic receptors, non-nicotinic receptors, and transporters; competes with the binding of nicotine.

Anti-inflammatory, insecticidal, and anticancer tetrahydrobenzofuran isolated from Aglaia species that inhibits TNF-α, NF-κB, NF-AT and various cytokines (IFN-γ, TNF-α, IL-2, and IL-4) with IC₅₀ values in the nanomolar range; induces apoptosis in human leukemia...

A selective, allosteric Bcr-Abl inhibitor (IC₅₀ = 267 nM) that does not affect native c-Abl or a panel of 63 additional kinases; antiproliferative toward Bcr-Abl-transformed cells (IC₅₀ = 138 nM), inducing apoptosis without cytotoxic consequences in nontransformed cells.

A potent and selective inhibitor of sPLA2 that exhibits 95% inhibition (XI(50)=0.003) of sPLA2 without affecting the activities of cPLA2 or iPLA2.

An orally bioavailable inhibitor of the HIV-1 protease (Ki =2 nM) that is used in combination with HIV reverse transcriptase inhibitors for the treatment of HIV infection.

A-66 is a potent, selective inhibitor of the PI3K isoform p110α (IC₅₀ = 32 nM in a cell-free assay). It displays over 100-fold selectivity for p110α over other isoforms. A-66 is effective in vivo, suppressing the growth of SK-OV-3 tumor xenografts in mice. It also impairs all...

Immunogen: Synthetic peptide from the C-terminal region of mouse protein PGIS Host: Rabbit Species Reactivity: (+) human, bovine, mouse, ovine, and rat PGIS Application(s): IHC and WB PGIS catalyzes the isomerization of PGH2 to PGI2 (prostacyclin), a potent vasodilator and inhibitor of platelet...

A phospholipid containing the tetramethylated long-chain (16:0) diphytanic acid inserted at the sn-1 and sn-2 positions.

A potent and selective antagonist of CaSR (IC₅₀ = 43 nM) that stimulates PTH secretion from parathyroid cells in vitro (EC₅₀ = 39 nM); causes a sustained increase in plasma PTH in rats when given intravenously.

An inhibitor of MAGL (IC₅₀ = 9.1 nM) and to a lesser extent ABHD6 with potent selectivity over FAAH (IC₅₀ > 10 µM) and other brain serine hydrolases; inhibits 2-AG hydrolysis (IC₅₀ = 2.1 nM) with no effect on AEA hydrolysis up to 50 µM; alleviates...

An anti-platelet aggregator (IC₅₀ = 180 µM, in vitro) that prolongs bleeding time significantly in a rodent model of thromboembolism; at ,24 mg/kg, generates antioxidant and neuroprotective effects against kainic acid-induced epilepsy in rat hippocampus.

A selective inhibitor of ASK1 (IC₅₀ = 3 μM; Ki = 500 nM); promotes survival of induced pluripotent stem cell populations and protects neurons from reactive oxygen species-induced apoptosis in a model of ischemia.

A metabolite of the natural purine base that is generated by DNA methylation and has been used as a probe of protein-DNA interactions and for DNA sequencing methods; carcinogenic biomarker for cigarette smoking that is detectable in urine.

The physiological actions of PGD2 include regulation of sleep, lowering of body temperature, inhibition of platelet aggregation and relaxation of vascular smooth muscle. PGD2 mediates its effects by 2 distinct G-protein-coupled receptors, DP1 and CRTH2/DP2. 15(R)-15-methyl PGD2 is a potent,...

19(R)-hydroxy PGF2α is an ω-1 hydroxylase metabolite of PGF2α found in human semen. The concentration of 19(R)-hydroxy PGF compounds (F2α and F1α together) in fresh human semen is about 20 µg/ml. 19(R)-hydroxy PGF2α exhibits no activity at the FP receptor of...

A dual purpose probe; a chemiluminescent probe that detects superoxide production by enzymatic and cellular sources; a fluorescent chloride-sensitive indicator, with fluorescence being quenched by chloride (excitation: 455 nm; emission: 505 nm).

Molecular Formula: C₁₃H₁₅IN₂O₂