Cayman Chemical

A widely-used insect growth regulator; acts as an activator of the juvenile hormone receptor, known as Methoprene-tolerant, or Met (Kd = 12.3 nM).

A triazole-containing plant growth retardant that is known to inhibit the biosynthesis of gibberellins.

Cayman’s Adipogenesis Assay provides the reagents required for studying the induction and inhibition of adipogenesis in the established 3T3-L1 model, using the adipogenesis induction procedure. This kit can also be used to screen drug candidates involved in adipogenesis. The classic Oil Red O...

A dietary carotenoid present in the macula region of the eye; high dietary intake correlates with reduced risk of age-related macular degeneration.

A selective activator of tumor-specific PKM2 (EC₅₀ = 92 nM) that binds to the dimer-dimer interface between two subunits of PKM2, inducing tetramerization; 50 mg/kg reduces tumor size, weight, and occurrence in mice bearing H1299 cell xenografts in a model of human non-small cell lung...

An inhibitor of class I HDACs with IC50 values of 0.9, 0.9, 1.2, and >20 μM for recombinant human HDAC 1, 2, 3, and 8, respectively; displays a wide spectrum of antitumor activity, particularly in tumors normally refractory to conventional anticancer agents.

A certified reference material categorized as a phytocannabinoid; considered an impurity in the commercial preparations of cannabidiol; intended for research and forensic applications

A CYP17 inhibitor (IC₅₀ = 300 nM) that competitively blocks synthetic androgen binding (EC₅₀ = 845 nM) and antagonizes the androgen receptor in transcriptional activation assays; inhibits the growth of castration-resistant prostate cancer cells (IC₅₀ = 2.9 µM).

A fluorinated building block for the synthesis of various pharmaceutical amides.

A target substrate for several of the histone modifying enzymes including lysine methyltransferases, arginine methyltransferases, acetyltransferases, and others.

A nucleotide that upon phosphorylation to GTP becomes incorporated into RNA; used to study modulation of glutamatergic neurotransmission.

A natural non-caloric sweetener with potential applications as a food additive or dietary supplement.

A pseudo-carbohydrate which inhibits α-glucosidases, inhibiting lysosomal α-glucosidase, sucrase, maltase, and isomaltase (IC₅₀s = 0.35, 0.11, 1.3, and 1.2 μM, respectively).

A potent inhibitor of autotaxin (IC50 = 2.8 nM in an in vitro enzyme assay); at 30 mg/kg, reduces LPA production by >95% following carrageenan-induced inflammation in rats and inhibits autotaxin activity in human whole blood (IC50 = 101 nM).

A potent, selective inhibitor of the V-ATPase from N. crassa with an IC₅₀ value of approximately 2 nM.

A macrodiolide antibiotic that displays anti-protozoal activity against both Plasmodium and Trypanosoma (IC₅₀s = 370 and 460 ng/ml, respectively) and cytotoxicity against MRC-5 cells (IC₅₀ = 870 ng/ml); enhances the anti-fungal activity of rapamycin.

The major tocopherol obtained from natural dietary sources is γ-tocopherol, whereas α-tocopherol is the form of Vitamin E typically obtained from synthetic supplements. γ-CEHC is a β-oxidized metabolite of dietary γ-tocopherol that functions as a natriuretic hormone. It...

Antigen: human MBOAT2, internal region (cytoplasmic) Host: rabbit Cross Reactivity: (+) human Application: FC and IF

An anhydro sugar formed during biofuel production from the fast pyrolysis of wood.

An antibiotic produced by S. sapporonensis that inhibits Gram-negative bacteria, including E. coli, Klebsiella, Shigella, Salmonella, Citrobacter, E. cloacae, and the pathogenic group of Neisseria.

A derivative of the photoactive probe psoralen that intercalates into DNA and forms DNA single-strand adducts and interstrand crosslinks when activated with UV light.

2-Imino-4-methylpiperidine is a potent, general NOS inhibitor. It exhibits IC₅₀ values of 0.1, 1.1, and 0.2 µM for inhibition of human iNOS, eNOS, and nNOS, respectively, at an arginine concentration of 30 µM.

Antigen: human ApoA1 protein amino acids 188-199 Host: rabbit Cross Reactivity: (+) human, mouse, and rat ApoA1 protein Application(s): ICC and WB ApoA1 is a major protein component of HDL. It acts as an acceptor for sequential transfers of phospholipids and free cholesterol from peripheral tissues...

A form of polymyxin B which terminates with 6-methyloctanamide; comparable to other B polymyxins in its ability to kill P. aeruginosa, A. baumannii, and K. pneumoniae isolates.