Cayman Chemical

Antigen: human adropin amino acids 34-76 Host: mouse, clone CC1133F5 Isotype: IgG1 Cross Reactivity: (+) human adropin Application(s): ELISA and WB

Oxidized low-density lipoprotein (oxLDL) particles contain low molecular weight species which promote the differentiation of monocytes and activate PMNL. Many of these substances were recently isolated and purified from oxLDL, and identified as phosphatidylcholine species containing a fragmented,...

An aminophenylthiazole that inhibits transient TMEM16A-mediated chloride currents with an IC₅₀ value of ~1 µM; blocks CaCC activity in vascular smooth muscle cells and relaxes mouse and human blood vessels.

A phenol product produced by the reaction of H₂O₂ with the ratiometric MS probe MitoB; quantifying the MitoP/MitoB ratio by LC-MS/MS reflects the mitochondrial matrix H₂O₂ concentration.

A ligand used for the purification of glucosidase I and II.

A dipeptide boronic acid derivative that reversibly inhibits the 20S proteasome (Ki = 0.6 nM); drives cell cycle arrest and apoptosis in cancer cell lines and has applications in multiple myeloma and certain lymphomas, as well as other types of cancer.

A selective inhibitor of VEGFR2 and PDGFR tyrosine kinases (IC₅₀s = 0.8 and 19.4 μM, respectively); inhibits VEGF-dependent angiogenesis in a zebrafish assay (IC₅₀ = 1.8 µM) without affecting normal cells; neuroprotective.

An immediate precursor used in the biosynthesis, by glucose addition, of storage polysaccharides in plants, green algae, and cyanobacteria, as well as structural polysaccharides in certain bacteria.

A reversible, selective, allosteric antagonist of mGluR7 that blocks agonist-induced calcium mobilization (IC₅₀ = 26 nM).

An analog of scriptaid that lacks scriptaid’s HDAC inhibitory effects; used as a negative control in experiments involving scriptaid.

An inhibitor of carbonic anhydrase, inhibiting human isoforms II, V, VI, IX, XII, XIII, and XIV with Ki values between 3.5 and 52 nM; less effectively inhibits human carbonic anhydrases I, III, and IV (Ki = 50, 8, and 8.5 μM, respectively); commonly used to treat glaucoma.

19(R)-hydroxy PGF1α is an ω-1 hydroxylase metabolite of PGF1α that has been identified in the semen of humans and marsupials. There are no published reports on its biological activity.

A natural phytochemical with anti-inflammatory effects; inhibits the growth of leukemia cells (IC₅₀ = 1.5 μg/ml), inducing apoptosis; at 15 μM, suppresses STAT3-regulated gene expression and prevents angiogenesis.

A small molecule enolase inhibitor.

A natural nitroaryl-substituted polyketide that exhibits antitumor, antifungal, and insecticidal activities; non-competitive inhibitor NADH:ubiquinone oxidoreductase of bovine heart, N. crassa, and E. coli (IC₅₀s = 0.07, 0.08, and 22 nmol/mg protein, respectively).

K252c is a cell-permeable PKC inhibitor (IC₅₀s = 2.45 and 25.7 µM for PKC and PKA, respectively). It induces apoptosis in human chronic myelogenous leukemia cancer cells. In human foreskin fibroblast cells, it reduces focus formation induced by human cytomegalovirus (HCMV) strains...

A potent anti-hypertensive vasodilator that functions by opening ATP-sensitive potassium channels; activates COX-1 (AC50 = 80 μM) increasing PGE2 production in BALB/c 3T3 fibroblasts and human dermal papilla fibroblasts.

A cell-permeable inhibitor that binds ERK2 near its docking domain (KD = 5 µM); blocks ERK-specific phosphorylation of Rsk-1 and TCF/Elk-1 but does not affect ERK1/2 phosphorylation by MEK1/2; completely prevents proliferation of several cancer cell lines.

Purified MIS for ELISAs.

A Pim kinase inhibitor that blocks mTORC1 activity via activation of AMPK, killing a wide range of both myeloid and lymphoid cell lines (with IC50 values ranging from 0.8 to 40 μM); induces G1 phase cell-cycle arrest, dose-dependent induction of p27Kip1, apoptosis through the mitochondrial...

A cell-permeable γ-secretase inhibitor (IC₅₀ = 0.14 nM) that has been shown to block Notch activation in vitro at 500 µM; induces apoptosis in Kaposi’s sarcoma cells, promotes intestinal goblet cell differentiation in a mouse model of colitis, and promotes neural...

A novel benzothiazole compound that inhibits Clk1/Sty and Clk4 (IC50 = 20 and 15 nM, respectively); at 1 μM, suppresses Clk-mediated phosphorylation which inhibits SF2/ASF-dependent splicing of β-globin pre-mRNA in vitro.

An inhibitor of SIRT1 and SIRT2, causing tumor-specific apopoptic cell death; causes 90% apoptosis within 72 hours (IC₅₀ ~ 20 μM) by reactivating proapototic genes that are repressed by SIRT1 in MOLT4 leukemia cells.

Thioetheramide-PC is a structurally modified phospholipid that functions as a competitive, reversible inhibitor of sPLA2. The IC₅₀ value for thioetheramide-PC is 2 µM at a substrate concentration of 0.5 mM. In addition to binding to the catalytic site of sPLA2, thioetheramide-PC...