FUJIFILM

Monocyte chemotactic protein 3 (MCP-3), also called CCL7, is produced by macrophages and tumor cell lines. MCP-3 signals through the G protein-coupled receptors CCR1, CCR2, and CCR3. MCP-3 chemoattracts monocytes and regulates macrophage function during inflammation and metastasis.

Visfatin is an adipokine produced by visceral adipose tissue. Visfatin acts as a pro-inflammatory factor for peripheral blood mononuclear cells (PBMCs) and mimics the effects of insulin on adipocytes, monocytes, and hepatocytes.

Macrophage inflammatory protein-3 beta (MIP-3 ß), also called CCL19, is a chemokine that is expressed in the thymus, lymph nodes, and activated bone marrow stromal cells. MIP-3 ß signals through the G protein-coupled receptor CCR7 to regulate normal lymphocyte recirculation. MIP-3 ß also functions...

Macrophage colony stimulating factor (M-CSF) is a hematopoietic growth factor that is widely produced by a variety of cells. M-CSF stimulates the proliferation and differentiation of hematopoietic stem cells into monocyte and macrophage cell types. M-CSF also acts through the colony stimulating...

Interleukin-19 (IL-19) is a member of the interleukin 10 (IL-10) cytokine family and is produced by B cells and monocytes. IL-19 binds the interleukin 20 receptor complex (IL-20R) to activate STAT3 signaling. IL-19 induces interleukin 6 (IL-6) and tumor necrosis factor alpha (TNF-a) expression in...

Interleukin 17AF (IL-17AF) is a heterodimer that is composed of the interleukin 17A (IL-17A) and interleukin 17F (IL-17F) members of the IL-17 family of cytokines. IL-17AF is produced by T helper 17 cells (Th17) following interleukin 23 (IL-23) stimulation. IL-17AF signals through the...

Leukemia inhibitory factor (LIF) is a member of the interleukin 6 (IL-6) family that is made by a variety of adult and embryonic tissues. LIF signals through the glycoprotein 130 (gp130)/LIF receptor (LIFR) heterodimer to activate STAT3 and MAPK signaling. LIF functions during hematopoietic...

Tumor necrosis factor alpha (TNF-a) is an inflammatory cytokine secreted by macrophages, monocytes, neutrophils, T cells, and NK-cells following stimulation by bacterial lipopolysaccharide (LPS). TNF-a signal activation occurs through two receptors, TNFR1 and TNFR2. TNFR1 is expressed on most cell...

Interleukin 17AF (IL-17AF) is a heterodimer that is composed of the interleukin 17A (IL-17A) and interleukin 17F (IL-17F) members of the IL-17 family of cytokines. IL-17AF is produced by T helper 17 cells (Th17) following interleukin 23 (IL-23) stimulation. IL-17AF signals through the...

Cytokines for mouse neuronal cell culture. Neural Stem Cells (NSC) are self-renewing cells, of the neural lineage, capable of generating neurons (GABA, dopamine and motor neurons), astrocytes and oligodenrocytes. NSCs are marked by expression of Nestin and can be derived from fetal neural stem...

Artemin is a neurotrophin member of the glial cell line-derived neurotrophic factor (GDNF) ligand family. Artemin is highly expressed in the adult pituitary gland, placenta, and trachea, and shows low level expression in the brain, spinal cord, and peripheral tissues. Artemin signals through the RET...

Interleukin 17F (IL-17F), a member of the IL-17 cytokine family, is secreted by activated CD4+ T cells and monocytes. IL-17F binds the IL-17 receptor related molecule, IL17RC, to promote the production of the interleukin 6 (IL-6), interleukin 8 (IL-8), and granulocyte macrophage colony-stimulating...

Interleukin 6 (IL-6) is a cytokine that is expressed by T cells, macrophages, and muscle cells. IL-6 acts to stimulate an immune response upon infection or trauma. IL-6 has both pro-inflammatory and anti-inflammatory functions, is capable of promoting fever, and signals through the cell-surface type...

Granulocyte-colony stimulating factor (G-CSF) is a cytokine that functions as a potent inducer of neutrophilic granulocyte proliferation, terminal differentiation, and activation. G-CSF synthesis occurs in monocyte, macrophage, epithelial, endothelial, and fibroblast cells after activation by...

Fibroblast growth factor 9 (FGF-9) is a mitogen and survival factor for nerve and mesenchymal cells. FGF-9 functions as an autocrine and paracrine factor to support the growth and survival of motor neurons and prostate tissue. FGF-9 expression in the gonad is also necessary for sex determination.

Growth differentiation factor 15 (GDF-15) is a member of the transforming growth factor beta (TGF-ß) family and is made by the placenta and cardiovascular tissues. GDF-15 regulates inflammatory and apoptotic pathways during cellular stress and injury. GDF-15 is emerging as a biomarker of early heart...

Tumor necrosis factor receptor type 1 (TNFR-1) is expressed in most tissues and is activated by soluble and membrane-bound tumor necrosis factor alpha (TNF-a). TNFR-1 activates NF-?B and MAPK pathways to induce inflammation, promote apoptotic cell death, inhibit tumorigenesis, and inhibit viral...

Insulin-like growth factor I (IGF-I) is a growth factor that is produced by the liver. IGF-1 production is stimulated by growth hormone (GH). IGF-I binds the insulin-like growth factor 1 receptor (IGF1R) and the insulin receptor to stimulate systemic body growth. IGF-I is one of the most potent...

Fms-related tyrosine kinase 3 ligand (FLT-3 ligand) is a growth factor that regulates hematopoietic cell proliferation. FLT-3 ligand signalling is transmitted through the fms-related tyrosine kinase 3 (FLT-3) receptor. FLT-3 ligand promotes the long-term expansion and differentiation of pro-B cells...

Transforming growth factors (TGFs) are multifunctional peptides that regulate growth and differentiation in most cell types. The TGF-ß family of proteins signal through serine/threonine kinase receptors. TGF-ß isoforms (TGF-ß1, -ß2, and –ß3) have overlapping, yet distinct biological actions in...

Interleukin 22 (IL-22), also called IL-TIF, is an IL-10 family member that is produced by activated dendritic cells and T lymphocytes. IL-22 signals via a heteroduplex receptor consisting of IL-22R and IL-10RB chains. IL-22 is a potent mediator of cellular inflammatory responses and wound healing.

Interleukin 17A (IL-17A), also known as CTLA-8, is a member of the IL-17 family of proteins. IL-17A is a proinflammatory cytokine that is secreted by activated CD4+ and CD8+ T lymphocytes. IL-17A acts through its receptor, IL-17R, to promote increased cytokine and chemokine secretion. In turn, the...

Insulin-like growth factor I (IGF-I) is a growth factor that is produced by the liver. IGF-1 production is stimulated by growth hormone (GH). IGF-I binds the insulin-like growth factor 1 receptor (IGF1R) and the insulin receptor to stimulate systemic body growth. IGF-I is one of the most potent...

WNT1-inducible-signaling pathway protein 2 (WISP-2) is a member of the CYR61/CTGF/NOV (CCN) family of regulatory factors. WISP-2 is expressed in ectodermal, mesodermal, and endodermal lineages, including primary osteoblasts, fibroblasts, mesenchymal stem cells, and adipogenic precursor cells. WISP-2...