Tumor necrosis factor receptor type 1 (TNFR-1) is expressed in most tissues and is activated by soluble and membrane-bound tumor necrosis factor alpha (TNF-a). TNFR-1 activates NF-?B and MAPK pathways to induce inflammation, promote apoptotic cell death, inhibit tumorigenesis, and inhibit viral replication.
Bioactivity Assay:Neutralization of human TNF alpha induced L929 cell cytolysis; ED50 =100 ng/mL; Bioactivity =1.0 x 10^4 units/mg