Cayman Chemical

Because of the rapid metabolism of PGE2, the determination of in vivo PGE2 biosynthesis is often best accomplished by the measurement of PGE2 metabolites. Cayman’s PGEM Assay converts all 13,14-dihydro-15-keto PGE2 and 13,14-dihydro-15-keto PGA2 into a single stable derivative, which is easily...

The Prostaglandin Screening Library II contains more than 60 “D and E-series” of prostaglandins in a 96-well Matrix tube rack format as 2 mM stocks in DMSO.

A selective inhibitor of PARP3 (IC₅₀ = 0.89 µM); cell permeable and elicits PARP3-specific effects at submicromolar concentrations.

A potent ghrelin receptor antagonist (IC50 = 1.1 nM) that inhibits hexarelin-stimulated food intake by as much as 98% in rats at 80 µg/kg; does not affect growth hormone release when tested in infant rats.

A structural analog of 14(15)-EET that demonstrates potent vasodilator agonist activity in bovine coronary arteries similar to that of 14(15)-EET.

A metabolite produced by fluorescent pseudomonads that is acetylated by MAPG acetyltransferase to form the broad-spectrum antibiotic, DAPG.

A cell-permeable diarylurea compound that inhibits apoptosome formation and caspase activation; blocks cytochrome c-induced caspase activation in HeLa cell cytosolic extracts with an IC₅₀ value of approximately 50 µM; suppresses caspase activation and apoptosis in cells treated with...

An aminopyridine compound that inhibits JNK1, JNK2, and JNK3 (Kis = 2, 4, and 52 nM, respectively); inhibits the phosphorylation of the JNK substrate c-Jun in HepG2 cells (EC₅₀ = 920 nM).

An oxidizing reagent that reacts with nitric oxide to form nitric dioxide and corresponding imino nitroxides.

Potassium Phosphate Stock Solution (500 mM, pH 7.0) contains filtered potassium phosphate (500 mM, pH 7.0). It is ready to use as supplied.

A selective inhibitor of K_v2.1 channels.

A non-peptide inhibitor of BACE1 (IC₅₀ = 239 nM) that demonstrates ~10-fold selectivity over BACE2 and >50-fold selectivity over other aspartyl proteases; decreases Aβ in APP-overexpressing cells and transgenic animal models and reduces C99 and sAPPβ, the two primary APP...

D-myo-Inositol-3,4,5,6-tetraphosphate (sodium salt) (Ins(3,4,5,6)-P4) is one of several different inositol oligophosphate isomers implicated in signal transduction. It almost completely inhibits calcium-activated chloride channels at a concentration of 8-10 µM. Related inositol oligophosphates...

An HIV protease inhibitor (EC₅₀ = 25 nM) that also inhibits CYP3A4, the primary cytochrome P450 isoform that metabolizes protease inhibitors; reduces the metabolism of concomitantly administered protease inhibitiors, enhancing their bioavailability and efficacy.

An orally-active quinoline-3-carboxamide that inhibits tumor angiogenesis and supplements radiation or chemotherapy in animal models of prostate cancer.

Cayman's Cortisol Express ELISA is a competitive assay that permits the rapid measurement of cortisol from biological samples, requiring only a two hour incubation and one hour development times.

Antigen: fusion protein from the C-terminus of the NR2A subunit of rat NMDA receptor Host: rabbit Cross Reactivity: (+) human, mouse, and rat NMDA receptor Application(s): IHC, IP, and WB The NMDAR plays an essential role in memory, neuronal development and it has also been implicated in several...

PI binds to double-stranded DNA and RNA after cells have been permeabilized. Once bound to nucleic acids, the nuclei appear red in color as observed by fluorescence microscopy with a rhodamine filter. PI is useful for multi-color fluorescent staining analysis. The bright red staining of nuclei makes...

A natural, broad spectrum Gram-positive antibiotic that inhibits two key enzymes in bacterial fatty acid synthesis, β-ketoacyl-ACP synthases II and III (FabF and FabH, respectively); IC₅₀ = 1.95 and 3.91 μg/ml, respectively; does not exhibit cross-resistance to antibiotic...

A potent, cell-permeable inhibitor of PARP1 (Ki = 50s = 1.3-5.5 μM); arrests tumor growth in mice bearing epigenetically silenced BRCA1 UACC3199 xenograft tumors.

An internal standard for the quantification of DHA by GC- or LC-MS.

A staurosporine derivative that binds to dephosphorylated c-Met kinase and to the colchicine binding site of tubulin; promotes mitotic arrest and apoptosis of various human tumor cell lines (EC₅₀s ranging from 60-600 nM).

A glycosylated derivative of trichostatin A that has been shown to induce the differentiation of a mouse erythroleukemia cell line and to increase histone H4 acetylation in B cells, though at higher concentrations than trichostatin A.

A FAHFA in which palmitic acid occurs at the 13-position on hydroxy stearic acid.