Cayman Chemical

A monohydroperoxy PUFA produced by the action of 15-LO on γ-linolenic acid.

A reversible acetylcholinesterase inhibitor that readily crosses the blood-brain barrier to reduce the breakdown of acetylcholine; commonly used in the treatment of Alzheimer’s disease to improve cognition, memory, and behavior.

Antigen: Peptide from the N-terminal region of human dopamine β-hydroxylase (DBH) Host: sheep Cross Reactivity: (+) Human and non-human primate tissue DBH Application: WB

A selective inhibitor of FAAH (IC₅₀s = 34 and 33 nM in rat and human, respectively) that is able to cross the blood-brain barrier.

A potent antagonist for the human IP (prostacyclin) receptor that antagonizes the carbaprostacyclin-induced activation of human neuroblastoma adenylate cyclase, blocking cAMP accumulation in a dose-dependent manner; inhibits the binding of tritiated iloprost to rodent neuroblastoma cells (Ki = ~ 3...

A red/orange-colored fat-soluble terpenoid with antioxidant properties; can be cleaved to produce vitamin A and retinoic acid.

Immunogen: Full length recombinant PAD4 protein Clone: 11F9 Host: Mouse Isotype: IgG1 Species Reactivity: (+) Human PAD4 Applications: ELISA, WB

A third generation aromatase inhibitor that blocks the conversion of androgens to estrogens in peripheral tissues (IC50 = 15 nM in human placenta in vitro) without interfering with cholesterol, cortisol, or aldosterone biosynthesis; used to treat estrogen receptor-positive breast cancers in...

Antigen: human Akt1 containing phospho-serine473 Host: mouse, clone 104A282 Isotype: IgG2κ Cross Reactivity: (+) human and mouse Akt1 Application(s): IP and WB Akt/PKB is a serine/threonine kinase that mediates cell survival and is thought to be a critical factor in the genesis of cancer. The...

A cell-permeable non-steroidal antagonist of the estrogen receptor GPER (Ki = 20 nM); displays low affinity cross-reactivity with the classical estrogen receptor, ERα, so that at doses greater than 1 µM it is capable of mediating limited ER-dependent transcriptional activity.

15(S)-15-methyl PGE2 is a potent, metabolically stable analog of PGE2. It is a potent gastric antisecretory and antiulcer compound. 15(S)-15-methyl PGE2 binds to human myometrium with twice the affinity of PGE2 and is ten times more potent than PGE1 in contracting uterine smooth muscle.

A mycotoxin produced by fungi of the Fusarium genus that is phytotoxic to various agriculture grain crops, cardiotoxic to poultry and rats, and cytotoxic to human red blood cell progenitors (IC₅₀ = 4.1 μM).

A dye that is commonly used in laboratories to stain or quantify proteins; typically gives blue bands on a clear background with a sensitivity of 50-100 ng/band; displays metachromasia by appearing pink-red, rather than blue, when binding certain proteins, such as collagen and histone H1.

Beclomethasone is a glucocorticoid.{52991} It reduces plasma corticosteroid levels in rats when administered at doses ranging from 1 to 10 mg/kg.

PGB2 is a non-enzymatic dehydration product resulting from the treatment of PGE2 or PGA2 with strong base. It has weak agonist activity on TP receptors and can increase pulmonary blood pressure in the rabbit at relatively high doses (5 µg/kg).

A triazole, antifungal agent that inhibits a broad range of pathogenic yeasts, including Candida (MIC = 0.03-8 µg/ml), and filamentous fungi such as Aspergillus, Scedosporium, and Fusarium by disrupting ergosterol synthesis.

A phospholipid containing the saturated long-chain (20:0) arachidic acid inserted at the sn-1 and sn-2 positions. It can be used in the generation of micelles, liposomes, and other types of artificial membranes.

Immunogen: peptide affinity-purified IgG Host: rabbit Species Reactivity: (+) human, bovine, and mouse sGC a1 subunit Application(s): WB Soluble guanylate cyclase is a heterodimeric enzyme, composed of α and β subunits, that synthesizes cGMP from GTP. The enzyme is activated by the...

A noncompetitive, irreversible α-adrenergic receptor antagonist (IC₅₀ = 34.2 nM for α1; Kis = 0.06, 0.01, and 0.06 µM for α2A, α2B, and α2C, respectively) with antihypertensive activity; covalently binds the adrenergic receptor, resulting in a blockade...

Antigen: synthetic peptide from human histone H3 Host: mouse, clone 117C826 Cross-Reactivity: (+) Human Histone H3 Application(s): WB H3 phosphorylation at serine 28 is coupled with mitotic chromosome condensation in diverse mammalian cell lines.

An orally bioavailable inhibitor of ACAT (IC₅₀s = 24 and 9.2 µM for ACAT1 and ACAT2, respectively) that reduces plasma total triglyceride and VLDL cholesterol levels in cholesterol-fed animal models; also used to decrease amyloid β generation in models of Alzheimer’s...

A more lipid soluble form of cis-12-octadecenoic acid.

A selective inhibitor of SUV420H1 and SUV420H2 (IC₅₀s = 25 and 144 nM, respectively) that inhibits the di- and trimethylation of H4K20me in multiple cell lines.

Cayman’s S-Nitrosylated Protein Detection Kit (Biotin Switch) employs a modification of the Jaffrey et al. 'Biotin-switch' method to allow for the direct visualization of S-nitrosylated proteins in whole cells or tissues, as well as by WB analysis. Using this method, free SH groups are...