Cayman Chemical

A potent inhibitor of DPP-4 (IC₅₀ = 18 nM); orally active, rapidly absorbed, and inhibits DPP-4 in plasma; lowers fasting plasma glucose, glycosylated hemoglobin, and two-hour postprandial glucose levels in patients with type 2 diabetes.

A PARP1 inhibitor (IC₅₀ = 450 nM) that displays neuroprotective effects in cultured mouse cortical neurons; also inhibits eosinophilic infiltration into airways of OVA-challenged mice and induces the regression of atherosclerotic plaques in high-fat fed ApoE(-/-) mice.

A yellow breakdown product of heme catabolism, formed when heme is cleaved by heme oxygenase; has key roles as a free radical scavenger with antioxidant and anti-inflammatory actions.

A water soluble, irreversible, broad spectrum inhibitor of serine proteases, including trypsin, chymotrypsin, plasmin, thrombin, and kallikreins; also inhibits NADPH oxidase.

A selective ERRβ/γ agonist (IC₅₀ = 2 µM) that can activate the receptor with similar potency as the protein ligand, PGC-1α.

A synthetic analog of natural PtdIns featuring C16:0 fatty acids at the sn-1 and sn-2 positions; contains the same inositol and DAG stereochemistry as the natural compound.

A membrane active peptide antibiotic of the peptaibol class that strongly induces helical peptide structures and forms voltage-gated ion channels in the lipid bilayers of cell membranes; often used to study ion channel assembly, voltage gating, and peptide-membrane interactions as well as to induce...

Cayman’s COX Fluorescent Inhibitor Screening Assay provides a convenient fluorescence-based method for screening ovine COX-1 and human recombinant COX-2 for isozyme-specific inhibitors. The assay utilizes the peroxidase component of COXs. In this assay, the reaction between PGG2 and ADHP...

The principal cytotoxic component of bee venom; assembles as tetramers on membrane surfaces to form pores, resulting in cell death.

A conjugate of biotin and lysine used for derivatization or conjugation to proteins and other molecules with a medium-chain length spacer; also used as an anterograde, retrograde, or intracellular neuroanatomical tracer that is fixable with aldehyde-based fixatives.

PAF C-18 is a naturally occurring phospholipid produced upon stimulation through two distinct pathways known as the “remodeling” and 'de novo' pathways. It is less potent than PAF C-16 in the induction of platelet aggregation, but equipotent in activation of guinea pig...

An IAA inhibitor of chloride channels that binds channels in bovine kidney cortex microsomes with a Ki value of 1 µM; reversibly inhibits CLIC proteins at 10 µM.

A potent inhibitor of all three human Pim kinases (IC₅₀s = 7, 363, and 69 nM for Pim-1, Pim-2, and Pim-3, respectively); induces apoptosis in lymphocytes from patients with CML or ALL; enhances the activity of sunitinib against renal cell carcinoma and resensitizes chemoresistant cancer...

Inhibits PAD4 activity (IC50 = 21.6 μM) as well as PAD1 and PAD3 activity (IC50s = 29.5 and 350 μM, respectively); cytotoxic to HL-60, MCF-7, and HT-29 cancer cell lines (IC50s = 0.5, 0.5 and 1 μM, respectively).

Stearic acid is a saturated fatty acid commonly found in animal and vegetable fats that is frequently used in cosmetics, candles, soaps, plastics, oil pastels, and for softening rubber. Ethyl stearate is the neutral, more lipid soluble form of the free acid. It perturbs the cell cycle and induces...

An inhibitor of tyrosinase (IC₅₀ = 0.9 mM), the enzyme that catalyzes the first step of the conversion of tyrosine to melanin.

A non-enzymatic, free radical peroxidation product of arachidonic acid; acts as a potent vasoconstrictor of porcine retinal and brain microvessels with EC50 values of 31 and 54 nM, respectively.

Antigen: fusion protein corresponding to amino acids 77-186 of human TRAF5 Host: mouse Cross Reactivity: (+) human and mouse TRAF5 Application(s): WB TRAF5, an adaptor protein that mediates signal transduction from TNF receptors, is implicated in NF-kB and c-Jun NH(2)-terminal...

An intravenous β-lactam antibiotic effective against a wide range of Gram-positive and Gram-negative bacteria (MICs range from 0.5-2 µg/ml for E. cloacae and P. aeruginosa), including several multi-drug resistant bacterial species.

A potent, stable, and selective agonist analog of AEA with a Ki value of 1.4 nM at the isolated rat CB1 receptor; 1,400 times more potent at the CB1 compared with the CB2 receptor; induces hypothermia in mice with the same efficacy as AEA, in spite of its much higher affinity for the CB1 receptor...

A dual inhibitor of 5-LO and COX pathways, inhibiting 5-LO, COX-1, and COX-2 (IC₅₀s = 0.75 μM, 0.65 μg/ml, and 1.2 μg/ml, respectively); may also inhibit other LO pathways in vivo.

A form of oleic acid with an ω-terminal alkyne for use in click chemistry reactions.

Antigen: human CB2 receptor amino acids 20-33 Host: rabbit Cross Reactivity: (+) human and mouse CB2 Application(s): IHC (formalin-fixed paraffin-embedded tissue) and WB This antibody has been raised against a sequence between the N-terminus and the first transmembrane domain of the protein of the...

A bacterial DNA gyrase inhibitor that disrupts supercoiling activity (IC₅₀ = 3.3 µM); demonstrates antibacterial activity against E. coli, P. aeruginosa, and S. enterica (MICs range from 10-80 µM).