Cayman Chemical

The COX Activity Assay utilizes the peroxidase component of cyclooxygenases. The peroxidase activity is assayed colorimetrically by monitoring the appearance of oxidized TMPD at 590 nm.The assay can be used to measure COX activity (COX-1 and COX-2) in cell lysates, tissue homogenates, and purified...

A nonpeptide angiotensin II receptor antagonist which selectively and insurmountably inhibits the angiotensin II AT1 receptor subtype (IC₅₀ = 2.7 nM); does not alter PPARγ activity.

The PLAs are an extensive family of lipid hydrolases that function in cell signaling, digestion, membrane remodeling, and as venom components. The iPLA2 are a PLA2 subfamily closely associated with the release of arachidonic acid in response to physiologic stimuli. (R)-BEL is an irreversible,...

A lipopeptide antibiotic effective against resistant Gram-positive bacteria (MIC90s range from 0.25-16 mg/L); alters bacterial plasma membrane potential and redirects the binding of proteins essential for cell division and cell wall synthesis.

A lipoic acid analog that inhibits α-ketoglutarate dehydrogenase, particularly in tumor cells; induces a strong mitochondrial burst of reactive oxygen species at 60-240 µM, resulting in cell death; demonstrates both in vitro and in vivo anti-tumor activity.

A synthetic CMR1/TRPM8 super agonist that is 2.5-fold more efficacious and nearly 200-fold more potent than the reference cold thermosensory agonist, l-menthol.

Antigen: peptide corresponding to a portion of human LSD1 amino acids 100-150 Host: rabbit Cross Reactivity: (+) canine, human, mouse, rat, Rhesus monkey, and zebrafish LSD1 Application(s): WB LSD1 functions as a transcriptional corepressor and catalyzes the flavin-dependent demethylation of Lys4 of...

DMABA-d4 NHS ester is intended for use in combination with DMABA NHS ester (Item No. 11216) as a derivatizing reagent for PE lipids in order to facilitate MS characterization and to quantify relative changes in their abundance.

A potent inhibitor of LSD1 (IC₅₀ = 0.02 µM) that less effectively inhibits MAO-A and MAO-B (IC₅₀s = 1.38 and 0.72 µM); blocks the expression of IE genes of HSV and hCMV in mammalian cells; represses HSV primary infection in mice and blocks HSV reactivation from...

A potent inhibitor of Mdm2-p53 binding (IC₅₀ = 0.09 µM); induces the expression of p53-regulated genes and exhibits potent antiproliferative activity in cells with functional p53; also called enantiomer a based on the elution pattern during chiral separation of (±) nutlin-3.

This nuclear receptor assay system utilizes proprietary non-human cells engineered to provide constitutive, high-level expression of the full-length human estrogen receptor 1 (NR3A1), a ligand-dependent transcription factor commonly referred to as ERα. INDIGO’s reporter cells include the...

A Nrf2 activator that interacts directly with the domain containing the Nrf2-binding site of Keap1; downregulates the expression of fibrogenic genes, producing antifibrotic effects in a rat model of nonalcoholic steatohepatitis.

A fluorescently-labeled cyclic nucleotide to study cyclic nucleotide-gated A2 channel activation; opens the channel in a rapid and reversible manner with efficiency equal to cGMP.

An internal standard for the quantification of PGE2-1-glyceryl ester by GC- or LC-MS.

8-iso-17-phenyl PGF2β is an isomer of bimatoprost (free acid) that is epimerized at the 8 and 9 positions. There are no published reports on the biological activity of 8-iso-17-phenyl PGF2β.

A polysulfated disaccharide that is used as a reference standard for sucralfate.

A pyrimidine nucleoside triphosphate that is involved in a variety of biochemical reactions, including RNA synthesis, the formation of PC, and sialylation.

Prostaglandin E2 (PGE2) is the major eicosanoid product of cyclooxygenase-1 and 2 in epithelial cells, leukocytes, reproductive tissues, and many others. PGE2 contracts smooth muscle, protects the gastric mucosa, modulates immune function, and regulates fertility and implantation. PGE2 acts through...

A selective Group III metabotropic glutamate receptor agonist that functions presynaptically to suppress glutamate release (IC₅₀ = 2.5 μM); depresses synaptic transmission in glutamatergic pathways in the hippocampus, olfactory bulb, and retina.

An unsaturated diacylglycerol with linoleic acid (18:2) side-chains attached at both the C-1 and C-3 positions that is useful for lipid research.

A classical nitroxyl (NO-) donor; dissociates in a pH-dependent, first order process with a half-life of 2.3 minutes at 37°C, pH 7.4, to liberate 0.54 moles for NO per mole of parent compound.

An agonist of TrkB (Kd = 320 nM) that protects TrkB-expressing neurons from apoptosis; neuroprotective in an animal model of Parkinson’s disease, reverses memory deficits in a mouse model of Alzheimer’s disease, and improves motor function and extends survival in an animal model of...

A CYP3A4 and CYP2E1 metabolite of acetaminophen that at high doses depletes liver reserves of glutathione, which allows hepatic proteins to become covalently modified by reactive metabolites and results in hepatocyte necrosis.

17-phenyl trinor 8-iso PGE2 is the C-8 epimer of 17-phenyl trinor PGE2, a synthetic analog of PGE2. 17-phenyl trinor PGE2 is an EP1 and EP3 receptor agonist that causes contraction of the guinea pig ileum at a concentration of 11 µM. There are no published studies of the pharmacological...