Cayman Chemical

PGD3 is produced by the metabolism of EPA via the COX pathway. It is equipotent to PGD2 in decreasing systemic blood pressure in rats and in decreasing intraocular pressure in rabbits. However, it is 3-5 times more potent than PGD2 in the inhibition of ADP-induced human platelet aggregation.

D-myo-Inositol-1,2,4,5-tetraphosphate (Ins(1,2,4,5)P4) is one of the many inositol phosphate (InsP) isomers that act as small, soluble second messengers in the transmission of cellular signals. Ins(1,2,4,5)P4 exhibits agonist activity at the Ins(1,4,5)P3 receptor expressed in CHO cells where it...

An irreversible quinazoline-based HER family tyrosine kinase inhibitor with IC50 values of 0.8, 19, and 7 nM for blocking in vitro activity of EGFR, HER2, and HER4, respectively; inhibits the proliferation of various tumor cells.

A lipophilic analog of 16-phenoxy tetranor PGF2α.

A stereoisomer of CCG-1423 that less potently inhibits MRTF-A-dependent cellular events, including SRF-mediated gene expression and cell migration.

A synthetic analog of natural PtdIns containing C8:0 fatty acids at the sn-1 and sn-2 positions; contains the same inositol and DAG stereochemistry as the natural compound.

A naturally occurring cytokinin that regulates cell division, development, and nutrient processing in plants and serves as a precursor to zeatin synthesis.

A potent inhibitor of MEK5 (IC₅₀ = 4.3 nM) and moderate inhibitor of ERK5 and TGFβR1 (IC₅₀s = 810 and 1800 nM, respectively).

A synthetic analog of natural PtdIns containing C8:0 fatty acids at the sn-1 and sn-2 positions; contains the same inositol and DAG stereochemistry as the natural compound.

An internal standard for the quantification of Latanoprost by GC- or LC-MS.

A natural indole alkaloid with demonstrated beneficial effects in cancer, obesity, inflammation, and many other conditions; an AhR antagonist (Ki = 28 nM), activator of TRPV1 (EC₅₀ = 45 nM), and inhibitor of signaling through NF-κB.

A nonspecific, irreversible inhibitor of serine proteases and other enzymes, including acetylcholinesterase, palmityl coenzyme A deacylase, arylsulfatase A, chymotrypsin, and trypsin; also known to block anandamide metabolism, which produces CB effects in mice, including antinociception,...

A selective, nonpeptide AT2R antagonist (IC₅₀ = 5.6 nM vs. 100 nM for AT1R) that has been used to selectively examine the specific roles for AT1R and AT2R in hypertensive and other vascular research-related models.

Antigen: phosphopeptide corresponding to amino acid residues surrounding phospho-Ser301 of rat Raf-1 Host: rabbit Cross Reactivity: (+) rat Raf-1; expected to react with bovine, canine, chicken, human, mouse, non-human primate, and Xenopus Raf-1 Application(s): WB Studies have shown that...

A chemical probe that specifically binds to the bromodomain of BRPF1 (Kd = 13 nM), inhibiting binding to tri-acetylated histone 4 (residues 1-21); potent in cells, with an IC₅₀ value of 250 nM.

The oxidized form of GSH that can be reduced back to GSH through the NADPH-dependent enzyme glutathione reductase; functions as a hydrogen acceptor in the enzymatic determination of NADP+ and NADPH and can be a proximal donor in S-glutathionylation post translational modifications.

A synthetic adrenal hormone, an androstanediol analog, that acts as an androgen receptor antagonist; inhibits androstenediol-dependent LNCaP cell tumor growth both in vitro (IC₅₀ = 6 nM) and in vivo.

This nuclear receptor assay system utilizes proprietary non-human cells engineered to provide constitutive, high-level expression of the full-length human estrogen receptor 2 (NR3A2), a ligand-dependent transcription factor commonly referred to as ERβ. INDIGO’s reporter cells include the...

Peptide sequence: PGP PGP is a tripeptide molecule and an established biomarker for COPD and CF. PGP functions as a neutrophil chemoattractant and is derived from the proteolytic cleavage of collagen in the extracellular matrix by a multistep cascade.

A natural antitumor inhibitor of cell adhesion to extracellular matrix that potently and selectively inhibits PP2A (IC₅₀ = 29 nM against the catalytic subunit), while having no effect against PP1, PP2B, or PP5.

A selective inhibitor of casein kinase 1ε (CK1ε; IC₅₀ = 32 nM) with greater than 20-fold selectivity over CK1δ; blocks CK1ε-mediated PER3 nuclear localization and PER2 degradation, both of which are proteins important for maintaining circadian rhythms in...

A protein cross-linking agent isolated from G. jasminoides Ellis; inhibits UCP2 activity; 5 µM genipin increases glucose-stimulated insulin secretion in isolated pancreatic islets chronically exposed to high levels of glucose; induces apoptosis in FaO rat hepatoma cells and human...

A natural guanidine-taurine analog derived from taurine; competitively inhibits taurine uptake by sodium-dependent taurine transporters in rat hepatocytes (Ki = 1.75 mM); a competitive glycine receptor antagonist in mouse striatal neurons.

An estrogen steroid hormone exclusively produced by fetal liver from estradiol and estriol during pregnancy; binds ERα with 4-fold higher affinity for over ERβ; exhibits estrogenic effects in bone, brain, vagina, and endometrium; acts as an estrogen antagonist in the presence of...