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A major oxysterol formed from cholesterol by CYP3A4/5; used as a marker for CYP3A4/5 activity.
A selective partial agonist of GPR120 that induces ERK activation and intracellular calcium responses in mouse enteroendocrine STC-1 cells that express GPR120 endogenously.
Antigen: human citrullinated fibrinogen Clone designation: 10E9.3 Host: mouse Cross Reactivity: (+) human Isotype: IgG2b Application(s): ELISA and WB
DAN-1 EE is a fluorescent indicator for the bioimaging of NO. DAN-1 EE is a cell permeable derivative of DAN, a molecule which has been used extensively in the quantitation of nitrate and nitrite using fluorescence spectroscopy. Upon entry into the cell, DAN-1 EE is transformed into the less cell...
A highly sensitive, stable substrate for HRP that reacts with H2O2 to produce the fluorescent compound resorufin; enables detection of H2O2 at a concentration as low as 5 pmol per 100 µl samples.
A synthetic analog of natural PtdIns featuring C8:0 fatty acids at the sn-1 and sn-2 positions; contains the same inositol and DAG stereochemistry as the natural compound.
An orally available, semi-synthetic penicillin antibiotic.
A purine analog with immunosuppressive effects; serves as a prodrug for 6-mercaptopurine, which alters purine processing and DNA synthesis, interfering with lymphocyte proliferation; used to benefit IBD, as well as additional diseases with immunological or autoimmunological components.
PGF2α methyl ester is an analog of PGF2α in which the C-1 carboxyl group has been esterified as the methyl ester. PGF2α methyl ester was one of the first PG esters shown to have ocular hypotensive activity. This compound continues to be a standard by which other ocular hypotensive...
A potent, selective, and orally bioavailable antagonist of MCP-1 binding to CCR2 (IC50 = 3.7 nM); inhibits chemotaxis in vitro (IC50 = 4.7 nM) and displays acceptable oral bioavailability in mice, rats, dogs, monkeys, and chimpanzees.
An intermediate in the synthesis of tetrahydrofolic acid in many non-mammalian organisms, including bacteria and fungi; metabolized by a variety of enzymes in mammals, including N-acetyltransferases; may also be utilized by bacteria or fungi that are living in mammalian organisms.
A potent inhibitor of calcium release-activated calcium channels in lymphocytes (IC50 = 100 nM); also inhibits lung IL-4 and CysLT generation in animal models of asthma.
A natural sesquiterpene that inhibits the proliferation of a wide range of tumors and enhances the effects of various chemotherapies; 10-40 µg/ml dose-dependently induces apoptosis and cell cycle arrest in the G2/M phase in HepG2 cells, upregulating Fas/FasL expression.
A secondary metabolite produced by some species of lichen that binds FAS-II enzymes to produce antibacterial and antiplasmodial effects; inhibits PfFabZ and PfFabI (IC50 = 10.7 and 36.1 µM, respectively) but shows low efficacy against the malaria parasite P. berghei (IC50...
A diglycan that binds galectins-1, -3, -8, and -9 with Kd values between 24 and 78 µM; used to investigate the roles of these galectins in cell signaling and carcinogenesis.
An endogenous ligand of the NOP1 (ORL1) receptor (Ki = 88 μM) involved in pain, memory, stress responses, anxiety, locomotion, and feeding behavior.
A potent and selective inhibitor of autotaxin, inhibiting recombinant autotaxin β with an IC50 value of 8.8 nM; inhibits LPA release from adipocytes (IC50 = 90 nM) and reduces plasma autotaxin activity by 57% when used at 5 μM.
A potent, selective, orally active inhibitor of COX-2 with an IC50 value of 10 nM and approximately 18,000-fold selectivity for COX-2 over COX-1
An inhibitor of FASN that strongly suppresses the growth of human breast cancer cell lines (IC50 = 21 µM for SK-BR-3 cells); also blocks the GTP-binding site of the cell division protein FtsZ from Bacillus, preventing bacterial division.
A β1-adrenergic receptor antagonist (Kis = 1.14 and 48.7 µM for β1 and β2, respectively); has applications in cardiology and vascular disease.
A thienyl cycloalkanone that is part of the NCI small molecule repository.
A selective inhibitor of the fibroblast growth factor receptor tyrosine kinase (IC50s = 0.2, 2.5, and 1.8 nM for FGFR1, 2, and 3, respectively); demonstrates antiproliferative activity in tumor cell lines expressing deregulated FGFRs (IC50s = 18-281 nM) and in an FGFR-driven...
A dual inhibitor of COX and 5-LO enzymes (IC50 = 0.73, 0.31, and 0.99 μM for COX-1, COX-2, and 5-LO, respectively, in whole blood).
The racemic version of a CYP450 metabolite of arachidonic acid that potently inhibits proximal tubule ATPase activity.