Antigen: human EP4 receptor N-terminal amino acids 1-22
Host: rabbit
Cross Reactivity: (+) human and ovine EP4 receptors
Application(s): WB
Binding of PGE2 to the EP4 receptor causes an increase in intracellular cAMP and subsequent relaxation of smooth muscle. In addition to sequence differences, EP4 receptors are distinguished from EP2 receptors by their insensitivity to the EP2 receptor selective agonist butaprost.