Cayman Chemical

An isomer of hypoxanthine that inhibits xanthine oxidoreductase (IC50 values between 0.2 and 50 μM); lowers serum and urinary uric acid levels in vivo and is used to treat gout and hyperuricemia.

A potent, selective inhibitor of p110δ.

Neutrophils are short-lived inflammatory cells that are highly adept at ingesting and destroying bacteria as part of the first line of defense in the innate immune response to many pathogenic organisms. They produce an extensive arsenal of defensive antimicrobial proteins and peptides including...

Antigen: recombinant human IL-33 Host: mouse, clone IL33026B Cross Reactivity: (+) human and mouse IL-33 Application(s): ELISA, IP, and WB IL-33, a member of the IL-1 family of cytokines, is expressed by many cell types following pro-inflammatory stimulation and is thought to be released on cell...

A water-soluble, diethylaminoethyl analog of the antineoplastic antibiotic rebeccamycin; intercalates into DNA, stabilizing the DNA-topoisomerase complex, resulting in potent catalytic inhibition of both topoisomerases I and II, DNA cleavage and apoptosis.

A racemic monohydroxy fatty acid cholesteryl ester found in atherosclerotic lesions.

A cell-permeable, selective, and reversible inhibitor of Syk (IC₅₀ = 41 nM); prevents FcεRI-mediated 5-HT release in RBL-2H3 cells in vitro (IC₅₀ = 460 nM) and inhibits passive cutaneous anaphylaxis reactions in mice (ID₅₀ = 13.2 mg/kg, s.c.).

A potent, cell-permeable inhibitor of SET7/9 (IC₅₀ = 2 nM) that demonstrates greater than 1,000-fold selectivity over a panel of 18 other methyltransferases.

An inhibitor of the ubiquitin ligase activity of PRC1; blocks BMI1/RING1A self-ubiquitination (IC₅₀ = 3.9 µM), as well as polyubiquitination of topoisomerase 2α in cells; inhibits ubiquitination of H2A by either RNF2 or RING1.

Ethyl palmitoleate is a more lipophilic form of the free acid. It is one of the fatty acid ethyl esters that increase cytosolic Ca2+ concentration leading to pancreatic acinar cell injury due to excessive consumption of ethanol. Ethyl palmitoleate (10-100 µM) in addition to 850 mM ethanol...

A prodrug that through dephosphorylation by alkaline phosphatase is converted to an active thiol, WR 1065 that has free radical scavenging, DNA protective, and hypoxia inducing activities; used to selectively reduce toxicity in normal tissues exposed to radiation or chemotherapeutic agents.

A pentameric chito-oligosaccharide involved in root nodulation; produced by NodC, a chito-oligosaccharide synthase, and serves as a substrate for NodL, an O-acetyltransferase; binds plant root lectins, an interaction that may be important in the promotion of cell division in the root cortex.

8-Hydroxyguanosine is produced by oxidative damage of RNA. It can be measured in cell digests or in biological fluids as a marker of oxidative stress. When 8-hydroxyguanosine (5-8 mM) is added to friend erythroleukemia cells, it acts as a growth inhibitor in addition to promoting differentiation.

An inhibitor of both FLT3 and JAK2 (IC₅₀s = 22 and 23 nM, respectively); blocks the activities of the FLT3 D835Y mutant, FLT3 with ITDs, and JAK2 with a V617F substitution (IC₅₀s = 6, 20-180, and 220 nM, respectively); orally bioavailable, inhibiting tumor growth and metastasis...

A small molecule, multi-targeted receptor tyrosine kinase inhibitor; blocks the autophosphorylation of both wild type and mutant forms of Kit in response to stem cell factor, resulting in cell death; active in vivo and commonly used against solid tumors in dogs.

Antigen: DYKDDDDK (identical to FLAGTM antigen) Host: rabbit Application: (+) WB; (−) IP

An aminopyridazine derivative that acts as a GABAA receptor antagonist that can be used as an intermediate in the synthesis of SR 95531.

An aminopeptidase B inhibitor that is commonly used to characterize novel proteases.

A potent, silent antagonist of serotonin 5-HT1A receptors (IC₅₀ = 2.2 nM; Ki = 0.8 nM) with 100-fold selectivity over other 5-HT subtypes; also exhibits agonist activity at dopamine D4 receptors (Kd = 2.4 nM).

A synthetic analog of retinoic acid that binds to retinoic acid receptors with similar efficiency as retinoic acid (Kis in the nM range) yet does not display affinity for cellular retinoic acid-binding protein (Ki = 540 µM).

An agonist of the group III metabotropic glutamate receptors mGluR4a and mGluR6 (EC₅₀s = 2-5 µM); mimics the phosphatidylserine head group and has been shown to inhibit the proliferation of microglia and to enhance neuronal differentiation of progenitor cells.

A selective, endogenous TRPV1 agonist that is a “hybrid” analog, which incorporates components of both the AEA-like and dopamine neurotransmitter pathways; binds to the human recombinant TRPV1 (Ki = 36 nM) with equipotency to that of capsaicin and slightly more potency than that of...

A potent ER antagonist that works by both down-regulating and degrading ERα; efficacious in the treatment of estrogen-sensitive breast cancer; fully activates ER on hippocampal neurons.

An ALK1 and ALK2 inhibitor (IC₅₀s = 1.8 and 1.1 nM, respectively) that can prevent BMP4-induced SMAD1/5/8 pathway activation in vitro (IC₅₀ = 100 nM) without affecting TGF-β signaling; less selective for ALK3, 4, 5, and 6 subtypes and the type II BMP receptor ActRIIA...