Cayman Chemical

An inhibitor of SRE activation in PC3 cells (IC₅₀ = 6.4 μM), with 87% inhibition of SRE activation achieved at 100 μM; inhibits PC3 cell migration (IC₅₀ = 4.2 μM), as determined by a scratch wound assay; causes no cytotoxicity when evaluated by WST-1 assay.

PGA2 is a naturally occurring prostaglandin in gorgonian corals where it may function in self defense. It is generally not present in mammals. PGA2 has low biological potency in most bioassays, but it does show some antiviral/antitumor activity. At a 25 µM concentration, PGA2 blocks the cell...

An oxygenation product of DHA that serves as a precursor to the anti-inflammatory, pro-resolving maresin 1; doses as low as 0.2 ng/mouse resulted in reduced infiltration of PMNs into sites of inflammation.

Fluprostenol is a well-studied, potent analog of PGF2α acting primarily through the FP receptor. β-Oxidation of fluprostenol yields 2,3-dinor fluprostenol. It is anticipated that this analog will be a prominent metabolite of the parent compound when administered to humans or other...

A bioactive saponin used in traditional Chinese medicine; has diverse protective effects for the cardiovascular, immune, digestive, and nervous systems.

A thymidine analog that is readily incorporated, following phosphorylation, into newly synthesized DNA in place of thymidine; can be detected immunologically in cells and tissues.

Immunogen: peptide from the an internal region of human protein Species-Reactivity: (+) human, mouse, ovine, and rat mPGES-1 Application(s): IHC and WB

A fluorescently-labeled analog of FTY720; methanol side chain of FTY720 that is targeted for phosphorylation by sphingosine kinases is retained, suggesting that it would likewise be phosphorylated in vivo.

Astaxanthin is a carotenoid pigment found primarily in marine animals including shrimp and salmon; it is a potent lipid-soluble antioxidant.

Lauric acid leelamide is the lauric (C-12) amide analog of leelamine. Leelamine has weak affinity for the human CB1 and CB2 receptors, exhibiting 20% displacement of [3H]-CP55940 at a concentration of 10 µM. Leelamine inhibits PDK with an IC50 value of 9.5 µM. Derivatives of leelamine...

Cayman's WST-8 Cell Proliferation Assay provides a tool for studying induction and inhibition of cell proliferation in any in vitro model. The assay is based on the extracellular reduction of WST-8 by NADH produced in the mitochondria resulting in a water-soluble formazan which dissolves...

A broad-spectrum, first-generation cephalosporin antibiotic that inhibits bacterial cell wall synthesis, causing growth to cease without lysis.

Nitroxyl (HNO) is the one electron reduced form of nitric oxide. Piloty’s acid is one of the best known and most widely used HNO donors. Under basic conditions Piloty’s acid decomposes to HNO and benzenesulfinate anion. The rate of HNO release at pH 7 is very slow (t½ = 5500...

An RSV inhibitor that demonstrates antiviral activity with an EC₅₀ value of 1.4 nM; interferes directly with RSV fusion (EC₅₀ = 5.4 nM), binding to the viral F protein.

Potent and selective antagonist for the CB1 receptor (Ki = 0.16-0.44 nM); a dose of 1-3 mg/kg improves the performance of rodents in working memory tasks; a dose of 30 mg/kg reduces caloric intake, increases lipolysis from fat tissues and reduces hepatic glycogen levels in rodents.

DepNA is one of several nitroaniline fatty acid amides which can be used to measure FAAH activity.{8928} FAAH is a relatively unselective enzyme in that it accepts a variety of amide head groups other than the ethanolamine of its endogenous substrate AEA. It also will hydrolyze fatty acid amides...

A selective BRD9 bromodomain inhibitor (pIC₅₀ = 7.3; pKd = 8.7); used to identify genes regulated by BRD9 in Kasumi-1 cells involved in cancer and immune response signaling.

Cayman’s MC4R Reporter Assay consist of a 96-well plate coated with a transfection complex containing DNA constructs for MC4R and a cAMP response element regulated Secreted Alkaline Phosphatase (SEAP) reporter (MC4R Reverse Transfection Strip Plate). Cells grown on the transfection complex...

A homolog of DHEA, characterized by the addition of an (R)-α-methyl group at the methylene carbon adjacent to the amide nitrogen.

The disaccharide component of sophorolipids; can be used in the synthesis of biosurfactants; demonstrates antibacterial, antifungal, spermicidal, virucidal, and anti-cancer activities.

An isomer of hypoxanthine that inhibits xanthine oxidoreductase (IC50 values between 0.2 and 50 μM); lowers serum and urinary uric acid levels in vivo and is used to treat gout and hyperuricemia.

A potent, selective inhibitor of p110δ.

Neutrophils are short-lived inflammatory cells that are highly adept at ingesting and destroying bacteria as part of the first line of defense in the innate immune response to many pathogenic organisms. They produce an extensive arsenal of defensive antimicrobial proteins and peptides including...

Antigen: recombinant human IL-33 Host: mouse, clone IL33026B Cross Reactivity: (+) human and mouse IL-33 Application(s): ELISA, IP, and WB IL-33, a member of the IL-1 family of cytokines, is expressed by many cell types following pro-inflammatory stimulation and is thought to be released on cell...