Cayman Chemical

The EP2 receptor is one of four GPCRs that mediate the actions of PGE2. The diverse effects of PGE2 acting via EP2 receptors point to the need to identify novel agonists and antagonists, both to further elucidate the function of this receptor subtype and for use as therapeutics for various diseases....

An inhibitor of Ras-mediated signaling that inhibits the growth of PANC-1 and U87 tumor cells with IC₅₀ values of 20 and 10 µM, respectively.

An antibiotic derived from P. chrysogenum that inhibits S. aureus and E. coli FabI (IC₅₀s = 40.1 and 33.2 µM, respectively); inhibits the growth of S. aureus, E. coli, and S. pneumoniae with MICs ranging from 32-64 µg/ml.

GW 7647 is a potent, selective agonist of human and murine PPARα. It activates human PPARα, PPARγ, and PPAR.delta. with EC50 values of 0.006, 1.1 and 6.2 µM, respectively, in a GAL4-PPAR binding assay. Similar EC50 values of 0.001, 1.3, and 2.9 were observed with the murine...

Chlorogenic acid is a phenolic natural product isolated from the leaves and fruits of dicotyledonous plants, including the coffee bean. Structurally, chlorogenic acid is the ester of caffeic acid with the 3-hydroxyl group of quinic acid. Chlorogenic acid is an important factor in plant metabolism....

A trifluoromethyl analog of an isatin sulfonamide compound that selectively inhibits caspases-3 and -7.

A selective, cell permeable inhibitor of CaMKII (IC₅₀ = 900 nM).

An internal standard for the quantification of N-butyryl-L-HSL by GC- or LC-MS.

BEL is a selective, irreversible, mechanism-based inhibitor of iPLA2 with a Ki value of 180 nM. It inhibits macrophage iPLA2 in a concentration-dependent manner with an IC₅₀ value of 60 nM.

A synthetic intermediate for pharmaceutical synthesis.

An α-glucosidase inhibitor that delays the absorption and digestion of dietary polysaccharides by reversibly inhibiting digestive enzymes such as maltase and sucrase (IC50s = 0.16 and 2.9 µM, respectively).

A potent, cell-permeable, reversible inhibitor of IKK2 (IC₅₀ = 13 nM); used to evaluate the role of the canonical, IκB-dependent NF-κB signaling pathway in cellular responses.

A novel agonist of SIP4 (EC₅₀ = 56 nM) that displays 37-fold selectivity against S1P5 (EC₅₀ = 2.1 μM) and no appreciable activity over the S1P1-3 subtypes at concentrations up to 25 μM.

Adenosine 3',5' cyclic monophosphate (cAMP) is a ubiquitous cellular second messenger that is a critical component of a signal transduction pathway linking membrane receptors and their ligands to the activation of internal cellular enzymatic activity and gene expression. cAMP is synthesized...

A semi-synthetic macrocyclic lactone prepared by the oxidation and oximation of an 80:20 ratio of milbemycin A3 and A4; nematocide and insecticide activity via the potentiation of glutamate and GABA-gated chloride-channel opening.

A potassium-sparing diuretic that promotes the loss of sodium and water from the body by directly blocking epithelial sodium channels (ENaCs); also blocks Na+/H+ exchangers (NHE-1) in the heart and acid-sensing ion channels (ASICs), which are involved in nociceptor responses to pH.

An antagonist of the inositol 1,4,5-trisphosphate at its carboxy terminus.

Antigen: human Trx1 Host: goat Application(s): IHC and WB

A potent inhibitor of PORCN (EC₅₀ = 0.5 nM); displays high stability in human plasma (t1/2 > 24 hours) and in zebrafish, but is much less stable in plasma from mice and rats; completely blocks Wnt/β-catenin-dependent developmental processes in zebrafish and in cultured mouse...

Antigen: recombinant human L-PGDS Host: rat, clone 10A5 Isotype IgG1κ Cross-reactivity: (+) human and mouse L-PGDS Applications: WB and IHC

An orally available, selective inhibitor of LSD1 (IC₅₀ < 20 nM); targets AML stem cells.

A selective inhibitor of ABHD6 (IC₅₀ = 10 nM) with negligible activity against other serine hydrolases such as DAGLβ; used both as a probe to study ABHD6 and as a negative control for studies of DAGLβ.

A dual inhibitor of mutant B-RafV600E and VEGFR2 (EC₅₀s = 0.14 and 0.19 µM, respectively, in cell-based assays) that also inhibits wild-type B-Raf, PDGFR, CSF1R, RET, c-KIT, SRC, and STE20 (IC₅₀s = 20-100 nM).

A reversible, cell-permeable inhibitor of the motor protein Eg5, blocking basal ATPase activity in vitro (IC₅₀ = 6.1 µM) and inducing the formation of monoastral spindles in cell-based assays (IC₅₀ = 51.3 μM).