Cayman Chemical

A selective inhibitor of ABHD6 (IC₅₀ = 10 nM) with negligible activity against other serine hydrolases such as DAGLβ; used both as a probe to study ABHD6 and as a negative control for studies of DAGLβ.

A dual inhibitor of mutant B-RafV600E and VEGFR2 (EC₅₀s = 0.14 and 0.19 µM, respectively, in cell-based assays) that also inhibits wild-type B-Raf, PDGFR, CSF1R, RET, c-KIT, SRC, and STE20 (IC₅₀s = 20-100 nM).

A reversible, cell-permeable inhibitor of the motor protein Eg5, blocking basal ATPase activity in vitro (IC₅₀ = 6.1 µM) and inducing the formation of monoastral spindles in cell-based assays (IC₅₀ = 51.3 μM).

Source: Recombinant protein expressed in E. coli Mr: 45.6 kDa

A natural product which effectively kills malarial parasites of the genus Plasmodium (IC50 = 4.0 nM); also used against a wide range of trematodes, including Schistosoma; has potential applications in certain types of cancer and inflammatory conditions.

A small molecule that stimulates the expression of PGC-1α and downstream genes in skeletal muscle cells, improving glucose utilization and fatty acid oxidation at a concentration of 20 μM; 15 mg/kg/day administered to diabetic db/db mice improved glucose tolerance, pyruvate tolerance, and...

A cell-permeable, selective inhibitor of calcineurin-mediated dephosphorylation of NFAT that does not disrupt other calcineurin-dependent pathways; disrupts NFAT-dependent expression of IL-2 and TNF-α when transfected in Jurak T cells and prevents the activation and proliferation of T cells...

A broad spectrum antibiotic that is in the β-lactam subclass known as carbapenems; effective against many Gram-negative and Gram-positive bacteria and is more effective against P. aeruginosa than other carbapenems; not effective against MSRA.

A potent group IVA cPLA2 inhibitor (XI(50) = 0.022); reduces thermal hyperalgesia evoked by carrageenan injection of rat hind paw (ED₅₀ = 1.2 mg/kg); does not inhibit COX activity or interfere with CB1 receptor signaling.

The Cayman Chemical glycerol tridocosahexaenoyl is suitable for use in research facilities and chemical laboratories to conduct wide range of experiments. It is available in sturdy bottle that endures heavy and rigorous usage.

A homolog of LOEA, characterized by the addition of an (R)-α-methyl group at the methylene carbon adjacent to the amide nitrogen.

An autoxidation product of DHA and a potential marker of oxidative stress in brain and retina where DHA is an abundant PUFA.

Binds avidly and selectively to the structurally-similar bromodomains of SMARCA4 and PB1(domain 5) with Kd values of 89 and 48 nM, respectively; also interacts with the bromodomain of SMARCA2; does not interact with other bromodomains or with a panel of kinases.

A synthetic catalytic scavenger of reactive oxygen species, with reduced activity compared to EUK 8 and EUK 134.

A potent and selective EP4 receptor antagonist (Ki = 24 nM); reverses the anti-inflammatory action of PGE2 in LPS - activated human macrophages at 100 nM.

20-ethyl PGE2 is an analog of PGE2 in which the ω-chain has been extended by the addition of two methylene carbon atoms. The only well studied prostaglandin analog with this structural feature is unoprostone, an F-series prostaglandin that is clinically approved as a glaucoma medication....

A substrate of cathepsin C that accumulates inside lysosomes causing lysosome degradation; 50 μM can inhibit the cathepsin-dependent activation of caspase-8.

AcylCoA:cholesterol acyltransferase (ACAT) is an intracellular cholesteryl ester synthase tied closely to the absorption of dietary cholesterol. OA is a weak inhibitor of ACAT with an IC50 of 26 µM. OA and the related glyceride dioleoyl phenylamino propane 1,2-diol have been linked to a...

A competitive, reversible inhibitor of cytidine deaminase (Ki values = 54 and 240 nM for human and E. coli enzymes, respectively).

A central component of energy storage and metabolism in vivo, providing the metabolic energy to drive metabolic pumps and serving as a coenzyme in a wide array of enzymatic reactions; acts a substrate for kinases involved in cell signaling and of adenylate cyclases that produce the second messenger...

A fluorogenic substrate of palmitoyl-protein thioesterase.

An inhibitor of human ACAT-1 and ACAT-2 with an IC50 value of approximately 60 µM for both enzymes; also inhibits copper-mediated oxidation of LDL by about 20% at a concentration of 3 µM.

A synthetic auxin that has been used to promote hypocotyl elongation during seedling emergence.

Antigen: portion of amino acids 100-150 of human SMAD3 Host: rabbit Cross Reactivity: (+) Bovine, canine, human, mouse, porcine, rat, and rhesus monkey SMAD3; predicted to react with chicken, Xenopus, and zebrafish SMAD3 Application(s): IHC and WB SMAD3 is a receptor-regulated SMAD (R-SMAD) that...