LiChrospher® RP-18 is a reliable and versatile traditionally produced spherical silica gel carrier with C-18 reversed phase properties. It is well suited for the separation of neutral, acidic and weak basic compounds. This sorbent is packed into a Hibar® 125-4 HPLC column. For mounting of a LiChroCART® 4-4 guard column, the guard column holder 1.51487 has to be used.