IL-10 is an anti-inflammatory cytokine produced by macrophages and type 2 T helper (Th2) cells. • Inhibits the production of pro-inflammatory cytokines such as interferon gamma (IFN?), tumor necrosis factor alpha (TNFa), interleukin 2 (IL-2), interleukin 3 (IL-3), interleukin 4 (IL-4), and granulocyte-macrophage colony-stimulating factor (GM-CSF), made by macrophages and regulatory T cells • Suppresses antigen presentation on antigen presenting cells, and enhances the survival, proliferation, and antibody production of B cells The biological activity of CTGrade GMP interleukins and growth factors is standardized, where applicable, to WHO International standards, providing cell and gene therapy developers consistent, lot-to-lot biological activity and performance.
Bioactivity Assay:Proliferation of MC/9 ; ED50 =5 ng/mL; Bioactivity =5.0 x 10^3 IU/µg