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A sialic acid analog that inhibits neuraminidase release of newly replicated influenza virus particles; selectively inhibits the growth of influenza A and B viruses in plaque reduction assays (IC50s = 5-14 nM) and to directly inhibit influenza A and B virus neuraminidases...
A small molecule inhibitor that potently and selectively inhibits both HDAC6 and HDAC8 (IC50s = 36 and 120 nM, respectively).
A derivative of PGF2β with increased water solubility.
Immunization of mice with chicken egg albumin (ovalbumin/OVA) in a precipitate complex with aluminum hydroxide (alum) is a highly effective means of inducing a potent TH2-mediated immune response. OVA/alum immunized mice produce anti-OVA antibodies predominantly of the IgG1 and IgE isotypes that...
A naturally-occurring tropane alkaloid that serves as an intermediate in the synthesis of a variety of bioactive alkaloids, many of which have potent neurological actions.
Esomeprazole is an inhibitor of the gastric H+/K+-ATPase and the (S) enantiomer of omeprazole (Item No. 14880).{61476} It reversibly inhibits the activity of the H+/K+-ATPase in an enzyme assay. Esomeprazole (30 mg/kg, s.c.) inhibits histamine-induced gastric acid secretion in rats. Formulations...
A potent synthetic α-galactosylceramide, which, in association with the antigen-presenting CD1d protein, activates NKT immune cells; has activity in many diseases, including cancer, lupus, diabetes, malaria, and tuberculosis.
A zwitterionic, long-chain acylcarnitine used to improve in vivo absorption of certain hydrophilic compounds, especially through mucosal membranes.
A broad spectrum kinase inhibitor that potently inhibits Aurora A, Aurora B, JAK2, JAK3, and c-ABL (IC50s = 3, 3, 1.2, 1.1, and 4 nM, respectively); potently (IC50 = receptor tyrosine kinases.
A first generation, selective SGLT inhibitor that blocks glucose transport with about 100-fold selectivity for SGLT2 (Ki = 6 nM; EC50 = 1.1 nM) over SGLT1 (Ki = 390 nM); 0.1 to 1.0 mg/kg increases urinary glucose excretion in both normal and diabetic rats, improves glucose tolerance in normal rats,...
A potent, competitive inhibitor of HMG-CoA reductase (Ki = 0.6 nM).
An antitumor benzothiazole that shows growth-inhibitory activity against several cancer cell lines.
A non-peptide antagonist of PAR1; blocks binding of haTRAP (IC50 = 70 nM) as well as platelet aggregation induced by either haTRAP or α-thrombin (IC50 = 0.3 and 3 µM, respectively); has no activity against PAR2, PAR4, or other receptors involved in platelet...
C-8 ceramide-1-phosphate is a short-chain analog of the naturally occurring ceramide-1-phosphate. The effects of C-8 ceramide-1-phosphate are essentially the opposite of C-8 ceramide; it induces DNA synthesis and cell division. The effects of C-8 ceramide-1-phosphate can be attenuated by...
A natural glycoinsolate found in cruciferous vegetables, including broccoli; converted to the isothiocyanate sulforaphane by the enzyme myrosinase, resulting in antioxidant, anti-inflammatory, and anti-carcinogenic effects.
A minor galactolipid present in oligodendrocytes and myelin, as well as comprises a major fraction of the lipids in photosynthesizing plants and green microorganisms; used as a marker for myelination.
Cyclooxygenase catalyzes the first step in the biosynthesis of prostaglandins, thromboxanes, and prostacyclins: the conversion of arachidonic acid to prostaglandin H2. Recent discoveries of the induction of cyclooxygenase by a variety of stimuli such as phorbol esters, lipopolysaccharides, and...
An analog of latanoprost (free acid) that contains a hydrogen sulfide releasing component; reduces IOP better than latanoprost in a rabbit model of glaucoma.
A cell-permeable, chromogenic substrate for β-galactosidase used in histochemical and molecular biology applications, including detection of lacZ activity in cells and tissues.
Catalase is an ubiquitous antioxidant enzyme that is present in most aerobic cells. It is involved in the detoxification of H2O2, a ROS that is a toxic product of both normal aerobic metabolism and pathogenic ROS production. Cayman’s Catalase Assay utilizes the peroxidatic function of catalase...
A synthetic analog of E-64, a potent and irreversible cysteine protease inhibitor; inhibits cathepsin B and L from rat liver with IC50 values of 8.7 and 3.5 nM, respectively.
An estradiol analog that binds to ERα with IC50 values in the range of 22-28 nM
Antigen: synthetic peptide from human HDAC11 amino acids 182-199 Host: rabbit Cross Reactivity: (+) human, mouse, and rat HDAC11 Application(s): WB HDAC11 is a class IV HDAC that is expressed in kidney, heart, brain, skeletal muscle, and testis.
A cell-permeable inhibitor of class IIa HDACs (IC50s = 126, 80, 36, and 19 nM for HDAC4, 5, 7, and 9, respectively).