Cayman Chemical

A small diffusible signaling molecule involved in quorum sensing, controlling gene expression, and affecting cellular metabolism; applications of this molecule include regulation of virulence, infection prevention, and septicemia in fish.

An ecdysteroid hormone produced in arthropod species that induces developmental changes associated with ecdysis and the completion of metamorphosis; used as a tool in inducible gene regulation systems controlled by reporter cells transfected with the ecdysone receptor.

A nucleoside reverse transcriptase inhibitor that, following triphosphorylation by thymidine kinase, potently blocks replication of HIV (EC₅₀ = 3 nM) with low cytotoxicity (CC50 > 5 μM).

Quorum sensing is a regulatory system used by bacteria for controlling gene expression in response to increasing cell density. This regulatory process manifests itself with a variety of phenotypes including biofilm formation and virulence factor production. Coordinated gene expression is achieved by...

A high affinity agonist of TSPO (Ki = 0.297 nM in rat whole brain) that exhibits IC₅₀ values of 2.73 and 3.04 nM, respectively, against human and rat glial TSPO; produces anxiolytic and antidepressant effects in various animal models, without inducing benzodiazepine-like adverse effects.

CAS Number: 940929-33-9 Molecular Formula: C₃₁H₃₃ClN₂O₃ • HCl Formula Weight: 553.5

Rosmarinic acid is a naturally-occurring phenolic compound with antioxidant and anti-inflammatory properties. This compound inhibits lipid peroxidation of rat liver microsomes by 90% at a concentration of 25 µg/ml. Rosmarinic acid suppresses endotoxin-induced activation of complement and...

9β-hydroxy stereoisomer of PGF2α; much less active than PGF2α in antifertility and bronchoconstrictor activities; exhibits bronchodilating activity in guinea pigs and cats and antagonizes the bronchoconstrictor activity of PGF2α.

A hybrid lipoic acid-TZD derivative that transactivates human PPARγ with an EC50 value of 10 µM.

Specifically inhibits the histone acetyltransferase Gcn5 (IC₅₀ = 100 μM) and can inhibit pre-RNA splicing with an IC₅₀ value of 0.5 mM.

Source: Active human recombinant N-term His-tagged protein expressed in E. coli Mr: 24.3 kDa One unit of enzyme produces one µmole of PGD2/min at 25°C in 100 mM Tris-HCl buffer, pH 8.0, containing 1 mM GSH, 1 mg/ml magnesium chloride, and 40 µM PGH2

A selective, orally bioavailable EZH2 inhibitor with K_i values that are less than 3 nM for wild type and Tyr646 mutant of EZH2; demonstrates significant tumor growth inhibition in a mouse xenograft model of human B cell lymphoma.

Synonyms Ampakine CX-516 Ampalex CX-516

A paramagnetic nitroxide spin label featuring a methanethiosulfonate group for site-directed spin labeling, particularly through disulfide linkages with cysteine residues on proteins.

Corey lactone aldehyde benzoate is a versatile, chiral intermediate used in the preparation of prostaglandins and prostaglandin analogs.

An inhibitor of CETP activity (IC₅₀ = 50 nM) that raises HDL cholesterol and reduces LDL cholesterol levels by blocking CTEP association with HDL.

A phospholipid containing the saturated long-chain (14:0) myristic acid inserted at the sn-1 and sn-2 positions.

An analgesic and antipyretic prodrug that is rapidly hydrolyzed to the metabolites 4-methylaminoantipyrine and 4-aminoantipyrine, which both inhibit COX activity (COX-1: IC₅₀s = 2.6 and 20.8 µM, respectively, and COX-2: IC₅₀s = 4.7 and 41.8 µM, respectively); binds...

Antigen: hamster brain SAF Host: mouse, clone SAF 83 Isotype: IgG Application(s): EIA, FC, and WB

An internal standard for the quantification of ent-8-iso-PGF2α by GC- or LC-MS.

A natural stilbenoid glycoside that is converted by glucosidases to rhapontigenin, a resveratrol analog.

A stable carbacyclic PGI2 analog of that inhibits ADP-induced platelet aggregation 25% at a concentration of 50 nM;10 mg/kg (oral) or 1 mg/kg (intraduodenal) prevents thrombotic arterial occlusion.

A CoA derivative used in fatty acid and polyketide synthesis and in the transport of α-ketoglutarate across the mitochondrial membrane; may mediate cancer cell cytotoxicity induced by fatty acid synthase inhibition.

A primary mono-oxygenation product of DHA in human whole blood, human leukocytes, and mouse brain; serves as a precursor to 17(S)-resolvins.