Cayman Chemical

A dual inhibitor of DNA-PK and PI3K.

A natural kavalactone that enhances the binding of bicuculline methochloride at the GABAA receptor at 0.1 µM.

A potent agonist of β-adrenergic receptors (pEC₅₀ = 8.13, 8.78, and 6.62 for human β1, β2, and β3, respectively).

A product of chlorophyll breakdown that has been used as a photosensitizer in photodynamic therapy for the treatment of cancer; inhibits glioblastoma cell growth (IC₅₀ = 2.8 µg/ml) and displays antiproliferative activity against melanoma, breast, and lung cancer cells in vitro at...

A selective agonist of GPR120 (pECM50s = 6.3, 6.2, and 6.1 at human, mouse, and rat receptors, respectively); dose-dependently stimulates insulin secretion by mouse insulinoma MIN6 cells under high glucose conditions.

A selective inhibitor of RIP1.

The NF-κB/Rel family of transcription factors is comprised of several structurally-related proteins that form homodimers and heterodimers and include p50/p105, p52/p100, RelA (p65), and c-Rel/NF-κB. Acting as dimers, these transcription factors bind to κB sites on DNA, thereby...

An inhibitor of both CDK1 and CDK2 (IC₅₀s =2.9 and 2.2 µM, respectively); inhibits cellular ataxia telangiectasia mutated and Rad3-realted kinase activity (IC₅₀ = 6.7 µM) and impairs G2/M arrest in various human cancer cells, potentiating the cytotoxic effects of...

A biologically active, immediate precursor of 7-epi jasmonic acid; plays a role independent of jasmonic acid activity in mediating resistance to pathogens and pests.

A peripherally acting, antihypertensive compound that competes with norepinephrine for transport into presynaptic terminals of adrenergic neurons by the norepinephrine transporter, reducing the release of norepinephrine in response to action potentials.

Fluprostenol-d4 contains four deuterium atoms at the 3, 3', 4, and 4' positions. It is intended for use as an internal standard for the quantification of fluprostenol by GC- or LC-MS.

An anxiolytic compound that causes hyperphagia, which likely due to its 10-fold selectivity for the 5-HT2B receptor; direct infusion of 1-3 µg into the cerebral ventricles of rats evokes maximal behavioral responses.

CAS Number: 1398065-69-4 Synonyms: Daxas-d₄ Molecular Formula: C₁₇H₁₀Cl₂D₄F₂N₂O₃ Formula Weight: 407.2

Antigen: peptide from human TLR8 within the region of amino acids 750-850 Host: mouse, clone 44C143 Cross Reactivity: (+) human and mouse TLR8 Application(s): FC (intracellular and cell surface), IHC (paraffin-embedded sections), and WB TLRs mediate innate immunity that is essential for microbial...

A potent inhibitor of IKKβ (IC₅₀ = 88-100 nM); used to elucidate roles for NF-κB both in cells and in vivo.

A nutlin-3 analog; inhibits the growth of HCT116 cells at high concentrations (IC50 = ~8 µM); promotes the growth of HCT116 cells ~40% at concentrations between 5-100 nM.

BH2 is a precursor of BH4 synthesis. It is a noncompetitive inhibitor of GTP cyclohydrolase I, with a Ki of 14.4 µM.

A cyclopentenone isoprostane produced by the action of reactive oxygen species on α-linolenic acid in plants; induces the expression of glutathione-S-transferase, increases phytoalexin biosynthesis, and triggers the expression of several genes involved in primary and secondary metabolism in...

An HMG-CoA reductase inhibitor (IC₅₀ = 5 nM); reduces low-density lipoprotein and C-reactive protein and increases high-density lipoprotein in clinical trials.

Iloprost is a second generation structural analog of prostacyclin (PGI2) with about ten-fold greater potency than the first generation stable analogs, typified by carbaprostacyclin. Iloprost binds with equal affinity to the human recombinant IP and EP receptors with a Ki of 11 nM. 15(R)-Iloprost is...

N,N-dimethyl-L-Valine is a synthetic intermediate useful for pharmaceutical synthesis.

A stable analog of ATP that acts as a potent agonist of G protein-coupled P2Y2 and P2Y11 receptors (pEC₅₀ = 5.52 for P2Y11).

A natural chalcone that has anti-inflammatory actions, supporting its use as a skin lightening agent, particularly for rosacea and atopic dermatitis; induces apoptosis and suppresses migration and invasion of cancer cells in vitro; has antibacterial and anti-parasitic actions.

A naturally-occurring but uncommon form of sphingosine, accounting for approximately 13% of the sphingosine in human skin; can be phosphorylated by sphingosine kinases to produce C-17 sphingosine-1-phosphate.