Cayman Chemical

Chemokine-Like Receptor 1 (CMKLR1) is a G protein-coupled receptor relevant to the cellular chemotaxis of dendritic cells and macrophages. This receptor is also expressed in brain, liver, lung, and kidney tissues. Chemerin (TIG2) has been identified as the natural ligand for this receptor. Resolvin...

A full GABAA agonist and partial GABAC agonist; binds GABAA on both high- and low-affinity sites (Kd = 10 and 270 nM, respectively), stimulating chloride efflux with an EC50 of 200 nM; activates GABAC receptors with an EC50 of 1.3 μM; impairs memory formation and retrieval; attenuates airway...

Antigen: human GPR17 amino acids 351-367 Host: rabbit Cross Reactivity: (+) human, mouse, and rat GPR17 Application(s): WB GPR17 is a GPCR that recognizes signals from both nucleotides and CysLTs. GPR17 is upregulated upon ischemic injury, and its inhibition has been shown to decrease ischemic...

A metabolite of sulindac that inhibits both COX-1 and COX-2 (IC50s = 1.9 and 1.21 µM, respectively); also inhibits aldose reductase (IC50 = 279 nM), blocking NADPH-dependent reduction of glucose to sorbitol, and reducing type 2 diabetic complications; inhibits colorectal cancer growth both in...

A competitive inhibitor of heme oxygenase that also inhibits soluble guanylyl cyclase and inactivates the NOS isoforms nNOS, iNOS, and eNOS (IC₅₀s = 0.8, 4, and 5 μM, respectively); used to assess iron status and to diagnose iron disorders and has shown therapeutic potential in...

An antifungal compound that is classified as an echinocandin, as it acts by noncompetititvely inhibiting the enzyme 1,3-β glucan synthase; effective against disseminated or invasive aspergillosis and candidiasis in mice and in humans.

A naturally occurring trans-fatty acid found in ruminant animals that is converted to 9(Z),11(E)-conjugated linoleic acid in mammals; reported to have beneficial antioxidant, anti-atherosclerotic, and antitumor activities.

An activator of sGC, stimulating activity at concentrations as low as 10-100 nM; inhibits platelet aggregation (IC50 = 36 nM), induces relaxation of preconstricted aorta rings (IC50 = 304 nM); effective in vivo, decreasing mean arterial blood pressure in hypertensive rats.

A reactive disulfide-containing, fluorescent probe (ex. max 502 nm; em. max 525 nm) designed for fast detection of H2S in biological samples and cells.

8-iso PGE2 is one of several isoprostanes produced from arachidonic acid during lipid peroxidation. It is a potent renal vasoconstrictor in the rat. 8-iso PGE2 inhibits U-46619 or I-BOP-induced platelet aggregation with IC₅₀ values of 0.5 and 5 µM, respectively. When infused into...

A quinolinone derivative that stimulates endogenous PGE2 generation in gastric mucosa, enhancing gastric mucosal defense in a COX-2-dependent manner; demonstrates gastroprotective, anti-inflammatory, and anti-oxidative effects; also enhances secretion of mucin covering the conjunctiva and cornea.

An inhibitor of TNF-a that prevents binding to the TNFR1 (IC50 = 22 µM).

A structural analog of NAADP that blocks NAADP-dependent calcium release (IC₅₀ = 6 nM) as well as NAADP binding to sea urchin egg homogenate (IC₅₀ = 0.4 nM); does not affect either IP3-mediated calcium release or cyclic ADP-ribose-mediated calcium release.

LTF4 is a cysteinyl-leukotriene produced in vitro, but not reported to date in vivo. It is formed by the incubation of LTE4 with γ-glutamyl transpeptidase and glutathione. LTF4 is a weak agonist in its ability to contract vascular smooth muscle. The rank order of potency of the...

An orally active, direct inhibitor of Factor Xa (Ki = 0.4 nM) that inhibits thrombin formation without prolonging bleeding time; approved for clinical use as an anticoagulant in the prevention of stroke and the treatment of venous thromboembolisms.

Metabolite of LTD4 and one of the constituents of SRS-A; considerably less active (8 to 12-fold) than LTC4 in the biological activities characteristic of CysLTs; urinary excretion of LTE4 is often used as an indicator of asthma.

Immediate precursor of 4-HNE formed from ω-6 hydroperoxides such as linoleic acid and arachidonic acid.

Antigen: human caspase-8 amino acids PVETDSEEQP Host: mouse, clone 90A992 Isotype: IgG1 Cross Reactivity: (+) human, chimpanzee, and Rhesus monkey caspase-8 Application(s): FC, IHC (paraffin-embedded tissue), and WB Caspase-8 forms a direct link between the activation of CD95 and the caspase...

Thioester analogs of glycerophospholipids, in combination with Ellman’s reagent, are convenient colorimetric substrates for the measurement of phospholipase activity. HEPC is a truncated analog of phosphatidylcholine with the entire sn-1 substituent deleted, and with a hexadecylthioester in...

An alkyl sulfonate that acts as an alkylating antineoplastic agent; forms both intra- and interstrand crosslinks on DNA, in addition to monoalkylation, primarily at guanine-N7, of DNA.

An ecdysteroid that drives molting in insects; binds the heterodimeric ecdysone receptor with nanomolar affinity.

Antigen: human adipose triglyceride lipase (ATGL) amino acids 382-400 Host: rabbit Cross Reactivity: (+) human, mouse, and rat ATGL Application(s): IHC (paraffin-embedded tissue) and WB ATGL is one of the key enzymes involved in the mobilization of fatty acids from triglyceride stores in adipose...

A potent, selective inhibitor of all three JNK isoforms (Ki values range from 25 to 50 nM); bioavailable when delivered by gavage, blocking JNK signaling and renal fibrosis in a rat obstructed kidney model; decreases hepatic necrosis and apoptosis after orthotopic liver transplantation in rats.

A dual inhibitor of DNA-PK and PI3K.