Cayman Chemical

Quantification of lipid peroxidation is essential to assess the role of oxidative injury in pathophysiological disorders. Lipid peroxidation results in the formation of highly reactive, unstable hydroperoxides of both saturated and unsaturated lipids. Cayman’s Lipid Hydroperoxide Assay...

A mycotoxin produced by A. ochraceus, A. carbonarius, and P. verrucosum that is commonly found as a food contaminant (Tolerable Weekly Intake = 100 ng/kg body weight per day); triggers nephropathy, induces renal adenomas, and initiates skin tumors through events involving oxidative stress,...

Antigen: human recombinant JMJD2D amino acids 1-354 Host: rabbit Cross Reactivity: (+) human and mouse JMJD2D Application(s): FC, ICC, IP, and WB JMJD2D is a lysine specific demethylase with emerging roles in histone modification or epigenetic remodeling.

A potent Syk inhibitor (IC₅₀ = 7.7 nM) that demonstrates 10-35-fold selectivity for Syk over a panel of 359 nonmutant kinases; used to reduce chronic lymphocytic leukemia cell survival and to disrupt chemokine signaling at nanomolar concentrations in conjunction with the PI3Kδ...

A selective, cell-permeable p70S6K inhibitor (IC₅₀ = 4 nM) that blocks phosphorylation of p70S6K in primary rat hepatocytes; demonstrates significant antitumor efficacy in both U87MG glioblastoma and HCT116 colon carcinoma xenograft models.

A metabolite of thyroid hormone.

An estrogen metabolite that acts as a substrate of MRP2 (Km = 75 µM), and through MRP2-mediated transport, functions as a cholestatic agent, decreasing bile flow.

BRD7552 is a small molecule that induces expression of pancreatic and duodenal homeobox 1 (PDX1), a transcription factor involved in pancreas development and function. BRD7552 dose-dependently increases PDX1 and insulin gene expression, as well as PDX1 protein levels, in PANC-1 cells. It also...

A structural analog of capsaicin with complex interactions in the CB system; inhibits the reuptake of AEA, acts as CB1 receptor agonist and is resistant to FAAH hydrolysis; exhibits vasodilator, analgesic, and anti-inflammatory properties.

A compound used to attach biotin to primary amines, such as lysines on the surface of proteins, under alkaline conditions (pH~8-9).

An ACC inhibitor (IC₅₀s = 53 and 61 nM for rat liver ACC1 and rat skeletal muscle ACC2, respectively); lowers malonyl-CoA levels and inhibits hepatic fatty acid and triglyceride synthesis both in vitro and in vivo.

A stain that permits the rapid, reversible detection of proteins immobilized on various matrices; used to locate proteins or evaluate efficiency of transfer, or an alternative to actin probing as a loading control; also used as a fiducial marker in mass spectrometric imaging.

A chemical probe for PRMT5 that potently inhibits the PRMT5/MEP50 complex from methylating histone H4 (IC₅₀ = 11 nM) in vitro; inhibits the symmetric arginine methylation of SmD3 (EC₅₀ = 56 nM) in Z-138 cells.

A potential cytochrome P450 metabolite of N-arachidonoyl taurine that may activate TRPV1 and TRPV4.

The dihydro derivative of Aflatoxin B1.

5(S)-HEPE is produced by 5-LO catalyzed oxidation of EPA. While the synthesis of 5(S)-HEPE from EPA by tissue homogenates has been demonstrated, the biological activity of 5(S)-HEPE is poorly documented. It remains to be determined whether this activity differs substantially from that of 5(S)-HETE...

A CB analog with a methyl group in the (R) configuration at C-2 of the ethanolamine group; is not a FAAH inhibitor and is nearly as susceptible to amide hydrolysis as AEA itself.

A biotinylated form of DEPMPO, which is used to spin trap reactive O-, N-, S-, and C-centered radicals; offers monitored biodistribution in cells, tissues and organs when used with an avidin-conjugated reporter; binds free radicals on proteins, producing adducts that can be analyzed via the biotin...

An end product of purine metabolism in humans that is mainly excreted in urine and can act as a potent peroxynitrite scavenger and antioxidant; high levels of serum uric acid (>120 µg/ml) are associated with gout, kidney stones, metabolic syndrome, hypertension, renal disease, and...

Antigen: fusion protein from the C-terminus of the NR2B subunit of rat NMDA receptor Host: rabbit Cross Reactivity: (+) human, rat, and mouse NMDA receptor Application(s): IHC, IP, and WB Overexpression of the NR2B-subunit of the NMDA receptor has been associated with increases in learning and...

A hybrid eicosanoid analog which incorporates the 'docsanoid' features of unoprostone as well as the 'prostamide' features of bimatoprost.

Source: human recombinant N-terminal His-tagged protein from Sf9 cells SPHK1 catalyzes the production of sphingosine-1-phosphate, a lipid mediator with broad spectrum of biological activities including cell proliferation, survival, migration, cytoskeletal organization, and morphogenesis.

A modestly selective NOS inhibitor with Ki values for inhibition of nNOS, eNOS, and iNOS of 5.3, 18, and 12 µM, respectively; however, does not show biologically significant selectivity for nNOS over eNOS, and instead favors iNOS (Ki/Km = 3.79, 5, and 0.96 µM, respectively).

An internal standard for the quantification of PAF C-16 by GC- or LC-MS.