Cayman Chemical

A long-acting ascorbic acid derivative that stimulates collagen expression and formation and is used in human cell culture; included in media to enhance the survival of human embryonic stem cells or drive osteogenic differentiation in human adipose stem cells and in human mesenchymal stromal/stem...

Caffeic acid is an inhibitor of 5-LO with an IC₅₀ value of 3.7-72 µM and 12-LO with an IC₅₀ value of 5.1-30 µM.

A bpV compound that selectivity inhibits PTEN (IC₅₀ = 31 nM); also inhibits the vascular endothelial PTP, PTP-β (IC₅₀ = 12.7 μM), and PTP-1βB (IC₅₀ = 61 μM) and is known to be an insulin mimetic capable of activating the insulin receptor kinase.

A β3-adrenergic receptor agonist (EC₅₀ = 22.4 nM) that displays potent selectivity for β3 compared to the β1 and β2 receptor subtypes (EC₅₀s ≥ 10 µM); relaxes rat and human bladder strips precontracted with carbamoylcholine (EC₅₀s = 5.1...

An endocannabinoid analog specifically designed to be a potent and selective inhibitor of the cellular uptake of AEA; inhibits the cellular uptake of tritiated AEA (IC50 = 3 µM) in RBL-2H3 cells, with negligible effects on the CB1 receptor and TRPV1.

A non-polar glycopeptide antibiotic produced by A. teichomyceticus that is broadly effective against Gram-positive bacteria.

C-2 ceramide is a cell-permeable analog of naturally occurring ceramides. It mediates many diverse biological activities, as do natural ceramides. These processes include differentiation of HL-60 cells, induction of apoptosis, activation of protein phosphatase 2A, and inhibition of the mitochondrial...

A dual inhibitor of Cdks and Aurora kinases; inhibits Cdk1/cyclin B, Cdk2/cyclin A, Cdk2/cyclin E, Cdk3/cyclin E, Cdk4/cyclin D1, Cdk6/cyclin D1, Aurora A, and Aurora B in vitro (IC₅₀s = 9, 4, 3, 58, 253, 175, 11, and 15 nM, respectively); blocks the growth of cancer cells in vitro and in...

The parent CysLT produced by the LTC4 synthase-catalyzed conjugation of glutathione to LTA4; potent inducer of bronchoconstriction and enhanced vascular permeability that contributes to the pathogenesis of asthma and acute allergic hypersensitivity.

A potent and selective G9a HMTase inhibitor (IC50 = 6 nM; Ki = 63 pM); more than 40,000-fold selective for G9a over SET7/9, SET8, PRMT3, and JMJD2E.

An immune response modifier that acts as a ligand of TLR7 and 8; demonstrates potent anti-tumor and anti-viral properties and has been used to study the innate immune response to viral infections.

A selective dual inhibitor of mTORC1 and mTORC2.

A benzylisoquinoline that acts as a neuromuscular blocking agent with slow onset and intermediate duration; causes non-depolarizing block of the neuromuscular junction.

A fluorogenic substrate for human leukocyte and porcine pancreatic elastase; excitation: 355-380 nm; emission 440-460 nm.

An antibiotic derived from S. hygroscopicus that acts as a potassium ionophore promoting K+/H+ exchange across mitochondrial membranes; used as a research tool to disrupt intracellular H+ and K+ concentration, thus altering pH, membrane potential, and cell volume.

An inhibitor of PI3Kα that is selective for p110α in vitro (IC₅₀ = 15 nM for p110α vs. >1 µM for other isoforms, as well as for mTOR) and in cells when used at 1 µM.

A selective inhibitor of p38α MAPK (IC₅₀ = 10 nM) that blocks IL-1β and TNF-α release in whole blood in vitro (IC₅₀s = 150 and 180 nM, respectively).

A lipophilic, nontoxic, iron-chelating agent that shows high iron chelation efficacy both in vitro in cell culture models and also in vivo in rats and mice.

CAS Number: 792173-99-0 Molecular Formula: C₁₇H₁₃N₅O₂ Formula Weight: 319.3

An internal standard for the quantification of cannabidiol by GC- or LC-MS; intended for research and forensic applications.

A mycotoxin produced from F. moniliforme that functions as an inhibitor of ceramide synthase (sphingosine N-acyltransferase).

An N-substituted 1,8-naphthalimide used as a fluorescent probe for various studies and as a precursor for protection of amine groups.

A natural imidazole-containing dipeptide that has antioxidant activities in cells, particularly against lipid peroxidation.

A cell permeable inhibitor of necrosis that also demonstrates strong mitochondrial reactive oxygen species and ONOO- scavenging activity; localizes in mitochondria, selectively blocking oxidative stress-induced necrotic cell death (0.1 μM necrox-5 inhibited ~50% cell death in H9C2 cells exposed...