All UM-SCC cell lines were derived in the lab of Dr. Thomas Carey at the University of Michigan and are exclusively distributed by Merck KGaA, Darmstadt, Germany. Access to UM-SCC cells is limited solely to those officers, employees and students of PURCHASER’s institution who need access to perform research. PURCHASER may not distribute UM-SCC cells or derivatives to third parties. PURCHASER shall comply with all applicable laws in its use and handling of the Product and shall keep it under reasonable safe and secure conditions to prevent unauthorized use or access.THIS PRODUCT IS ONLY AVAILABLE FOR SALE TO ACADEMIC INSTITUTIONS OR NOT-FOR-PROFIT ENTITIES FOR USE UNDER THIS LIMITED USE LABEL LICENSE. FOR INFORMATION ON COMMERCIAL LICENSING OF UM-SCC CELLS, INCLUDING LICENSING TO COMMERCIAL ENTITIES, PLEASE CONTACT: [email protected] and neck squamous cell carcinoma (HNSCC) develops from the mucosal linings of the upper aerodigestive tract, comprising 1) the nasal cavity and paranasal sinuses, 2) the nasopharynx, 3) the hypopharynx, larynx, and trachea, and 4) the oral cavity and oropharynx. Squamous cell carcinoma (SCC) is the most frequent malignant tumor of the head and neck region. HNSCC is the sixth leading cancer by incidence worldwide. There are 500,000 new cases a year worldwide and two thirds occur in industrialized nations. It is caused by tobacco and alcohol consumption and infection with high-risk types of human papillomavirus (HPV). SCC often develops from preexisting dysplastic lesions. The five-year survival rate of patients with HNSCC is about 40-50%.UM-SCC-1 is a unique head and neck squamous carcinoma cell line isolated from the tumor located on the floor of the mouth of a male patient. The cell line is negative for HPV-16 and for HLA-A2, a class I molecule of the major histocompatibility complex (MHC). The UM-SCC-1 cell line is 50% more invasive in vitro and displays a greater propensity for perineural and lymphatic invasion in vivo. UM-SCC-1 was established at the University of Michigan (1) with written informed consent obtained from the patient and with the approval of the study by the Medical School Institutional Review Board.Reference: 1) Carey, T., et al. (2012) Genotyping of 73 UM-SCC head and neck squamous cell carcinoma cell lines. Head Neck. 2010 April; 32(4): 417–426.
Synonyms: University Michigan Squamous Cell Carcinoma, UMSCC1, H&N squamous cell carcinoma cell line, Head and neck squamous cell carcinoma cell line, HNSCC