Transforming growth factor beta 1 (TGFß1) is the prototype of a growing superfamily of peptide growth factors and plays a prominent role in a variety of cellular processes, including cell-cycle progression, cell differentiation, reproductive function, development, motility, adhesion, neuronal growth, bone morphogenesis, wound healing, and immune surveillance. TGF-ß1, TGF-ß2 and TGF-ß3 signal via the same heteromeric receptor complex, consisting of a ligand binding TGF-ß receptor type II (TßR-II), and a TGF-ß receptor type I (TßR-I). Signal transduction from the receptor to the nucleus is mediated via SMADs. TGF-ß expression is found in cartilage, bone, teeth, muscle, heart, blood vessels, hematopoietic cells, lung, kidney, gut, liver, eye, ear, skin, and the nervous system.
Recombinant Mouse TGF-ß1 produced by a mammalian expression system is a polypeptide chain containing 112 amino acids. A fully biologically active molecule; rm TGF-ß1 a molecular mass of 12.8 kDa analyzed by reducing SDS-PAGE and is obtained by chromatographic techniques at GenScript.