Staurosporin is an antibiotic which is isolated from Streptomyces species, possesses inhibitory activity against fungi and yeasts. It is potent inhibitor of phospolipid/Ca2+ dependent and cyclic nucleotide dependent protein kinases, a potent protein kinase inhibitor useful as a tool for studies on protein phosphorylation in the regulation of cellular functions.
Staurosporin is used to study the involvement of protein kinases in signal transduction pathways. It arrests normal cells in the G1 checkpoint. Staurosporin is used as a potent inhibitor of Protein kinase C and other protein kinases in vitro and in cultured cells, an inducer of apoptosis in many mammalian cell types.
Potent inhibitor of phospholipid/calcium-dependent protein kinase. Inhibits the upregulation of VEGF expression in tumor cells. Partially reverses MDR, sensitizing cells with MDR phenotype to cytotoxic agents. Inhibits Pgp phosphorylation. However, functional significance of Pgp phosphorylation is ill defined.
Purity: ≥98%
Key Applications: Staurosporine can cross cell membranes in 0.5 to 2.0 hours and has been shown to function in both plant and mammalian systems
Application Areas: Chemicals, Life Sciences
Product Type: Biochemicals
Biochemical Category: Antibiotics
Melting Point: 237°C
Solubility: May be reconstituted by dissolving the lyophilized reagent in DMSO (5 mg/mL-clear, colorless solution), DMF, ethyl acetate (5 mg/mL-clear colorless solution) or methanol or water.
Storage & Handling: Store at 2-8°C & Protect from light.