Silylation Grade Solvents are manufactured to meet exacting silylation needs.
- Purified, dried and packaged under nitrogen in convenient 50mL Hypo-Vial Sample Storage Vials
- Supplied with elastomer septa, allowing immediate access to the sample without exposure to moisture and oxygen
- Use polar solvents (acetonitrile, dimethylformamide, dimethylsulfoxide, pyridine, tetrahyrdrofuran) to facilitate reactions; nonpolar organic solvents may be used, but they will not accelerate the rate of reaction
Recommended for:
- Avoid water or alcohol because TMS reagents react with active hydrogen; avoid enolizable ketones
- Use dimethylformamide for steroids and other large molecules
- Use dimethylsulfoxide to prepare TMS derivatives of tertiary alcohols and some compounds with reluctant solubility in other silylation solvents
- Pyridine is an excellent solvent and reaction medium for MS reactions and is an HCl acceptor in reactions involving organochlorosilanes
- Other commonly used solvents include tetrahyrdrofuran and acetonitrile