Synonym(s): IGF-II
Purity: ≥97% (SDS-PAGE)
Physical form: Lyophilized from a 0.2 μm filtered solution containing 100 mM acetic acid.
Analysis Note: The biological activity is measured in a serum-free cell proliferation assay using the human cell line MCF-7.
Storage: −20°C
Biochem/physiol Actions: IGF-II also known as multiplication stimulating activity (MSA), shows virtually identical bioactivities as IGF-I. Expression of IGF-II is highest in fetal tissues, where it is believed to play a major role in overall growth and development. After birth IGF-II expression decreases to much lower levels in a variety of tissues. IGF-II is produced also in several tumors. IGF-II binds to IGF-II receptor (IGF-IIR), to IGF-IR and weakly to the insulin receptor (IR). All IGF-II bioactivities in adult tissues are generally attributed to its interaction with IGF-IR. However, during embryogenesis the roles of both IGF-IIR and IR may be significant in promoting normal growth.
Empirical Formula (Hill Notation): C14H10O3