Fumitremorgin C, from Neosartorya fischeri, film

Synonyms: FTC

CAS Number: 118974-02-0

Formula: C22H25N3O3

Formula Weight: 379.45

Linear Formula: C22H25N3O3

MDL No.: MFCD08702652

Storage: 2-8C

UNSPSC Code: 12161501

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General description: Chemical structure: indol derivative

Biochem/physiol Actions: Fumitremorgin C (FTC) is a fungal toxin of the diketopiperazines family of compounds. In mammalian cells, FTC is tremorgenic and causes cell cycle arrest. Fumitremorgin C has been shown to reverse resistance to doxorubicin, mitoxantrane, and topotecan in non-Pgp (P-glyco­protein), non-MRP (multidrug resistance protein) multidrug-resistance (MDR) cells. This reversal of resistance is associated with an increase in drug accumulation. Fumitremorgin C is a specific, selective, and potent inhibitor at micromolar concentrations of the breast cancer resistant protein (BCRP/ABCG2), an ABC transporter associated with chemotherapy resistance. FTC, in combination with mitoxantrone, can be used for the detection of ABCG2 functional activity in several cell lines.