FGFR3 (397-end), active, GST tagged human, PRECISIO(R) Kinase, recombinant, expressed in baculovirus infected Sf9 cells, >=70% (SDS-PAGE), buffered aqueous glycerol solution

Synonyms: ACH; CD333; CEK2; HSFGFR3EX; JTK4

Purity: >=70% (SDS-PAGE)

Activity: activity: 95-129 nmol/min·mg

Storage: -70C

UNSPSC Code: 12352200

General description: FGFR3 (fibroblast growth factor receptor 3) is a receptor tyrosine kinase (RTK), and belongs to the FGFR subfamily. This subfamily includes four members namely, FGFR1, FGFR2, FGFR3 and FGFR4. It contains a ligand-binding region in its exoplasmic domain, a single transmembrane region and a tyrosine kinase domain in its intracellular domain.

Biochem/physiol Actions: FGFR3 (fibroblast growth factor receptor 3) plays an essential role in the signaling pathways during embryogenesis. Aberration in FGFR3 signaling is linked with developmental disorders and cancer. This gene is either mutated or up-regulated in nonmuscle-invasive urothelial carcinoma (UC) of the bladder, and is also linked with metastasis and muscle-invasiveness of UC.

Physical form: Supplied in 50 mM Tris-HCl, pH 7.5, with 150 mM NaCl, 0.2 5mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, and 25% glycerol.