Recombinant human ß-NGF is expressed in human 293 cells as a homodimer (non-disulfide bonded) of 120 amino acids, with a calculated molecular weight of 13.5 kDa (monomer). Nerve growth factor ß (ß-NGF) is a neurotrophic factor structurally related to BDNF, NT-3 and NT-4. The production of natural ß-NGF occurs in epithelial cells, and the pituitary gland.
Synonyms: beta-NGF; BNGF; NGF-beta; NGF-beta
Purity: >=95% (SDS-PAGE)
Storage: -20C
Biochem Physiol Actions: Nerve growth factor ß (ß-NGF) is a potent neurotrophic factor that signals through its receptor ß-NGFR, and plays a crucial role in the development and preservation of the sensory and sympathetic nervous systems. ß-NGF promotes the survival and cholinergic phenotype of basal forebrain cholinergic neurons and stimulates neurite outgrowth of embryonic trigeminal motor neurons in vitro.