Synonyms: N-((6-Fluoro-2,3,4,9-tetrahydro-1H-carbazol-3-yl)methyl)-4,4-bis(4-fluorophenyl)butan-1-amine; N-[4,4-Bis(4-fluorophenyl)butyl]-6-fluoro-2,3,4,9-tetrahydro-1H-carbazole-3-methanamine
Molecular Formula: C29H29F3N2
Molecular Weight: 462.55
Linear Structural Formula: C29H29F3N2
Purity: >=98% (HPLC)
Storage: 2-8C
Biochem Physiol Actions: MSC1094308 is a reversible, non-ATP-competitive, type I AAA ATPase VPS4B-selective allosteric inhibitor (IC50 = 0.71 muM) with =10-fold reduced potency toward the type II AAA ATPase VCP/p97 and NSF (IC50 = 7.2 and >40 muM, respectively). MSC1094308 specifically inhibits p97-mediated Ub-GFP degradation without affecting proteasome-dependent ODD-luc degradation using a dual reporter HeLa cell line (10 muM) and exhibits comparable efficacy as DBeQ against 50 ng/mL TNFalpha-induced IkappaBalpha degradation in HeLa cells (10 muM).