LIPODEX® cyclodextrin phases
Capillary columns for GC enantiomer separation
Features
- Base material: cyclic oligosaccharides consisting of six (α-cyclodextrin), seven (β-cyclodextrin) or eight (γ-cyclodextrin) glucose units bonded through α-1,4-linkages
- Regioselective alkylation and/or acylation of the hydroxyl groups leads to lipophilic phases with varying enantioselectivity, which are well suited for GC enantiomer analyses.
- Important advantage: many compounds can be analyzed without derivatization (however, for certain substances enantioselectivity can be favorably influenced by formation of derivatives)
A large number of separations have been achieved, however, it is not possible to make a general prediction, which phase could solve a given separation task. Even for compounds with small structural differences or within homologous series the enantiodifferentiation can be quite different. The descriptions below list some of the typical separations possible with individual phases.
LIPODEX® A · hexakis-(2,3,6-tri-O-pentyl)-α-cyclodextrin
- Recommended for carbohydrates, polyols, diols, hydroxycarboxylic acid esters, (epoxy-) alcohols, glycerol derivatives, spiroacetals, ketones, alkyl halides
- Max. temperature for isothermal operation 200 °C, max. temperature for short isotherms in a temperature program 220 °C
LIPODEX® B · hexakis-(2,6-di-O-pentyl-3-O-acetyl)-α-cyclodextrin
- Recommended for lactones, diols (cyclic carbonates), aminols, aldols (O-TFA), glycerol derivatives (cyclic carbonates)
- Max. temperature for isothermal operation 200 °C, max. temperature for short isotherms in a temperature program 220 °C
LIPODEX® C · heptakis-(2,3,6-tri-O-pentyl)-β-cyclodextrin
- Recommended for alcohols, cyanhydrins, olefins, hydroxycarboxylic acid esters, alkyl halides
- Max. temperature for isothermal operation 200 °C, max. temperature for short isotherms in a temperature program 220 °C
LIPODEX® D · heptakis-(2,6-di-O-pentyl-3-O-acetyl)-β-cyclodextrin
- Recommended for amines (TFA), aminols (TFA), trans-cycloalkane-1,2-diols, trans-cycloalkane-1,3-diols (TFA), β-amino acid esters
- Max. temperature for isothermal operation 200 °C, max. temperature for short isotherms in a temperature program 220 °C
LIPODEX® E · octakis-(2,6-di-O-pentyl-3-O-butyryl)-γ-cyclodextrin
- Recommended for α-amino acids, α- and β-hydroxycarboxylic acid esters, alcohols (TFA), diols (TFA), ketones, pheromones (cyclic acetals), amines, alkyl halides, lactones
- Max. temperature for isothermal operation 200 °C, max. temperature for short isotherms in a temperature program 220 °C
LIPODEX® G · octakis-(2,3-di-O-pentyl-6-O-methyl)-γ-cyclodextrin
- Recommended for menthol isomers, ketones, alcohols, carboxylic acid esters, terpenes
- Max. temperature for isothermal operation 220 °C, max. temperature for short isotherms in a temperature program 240 °C