Antigen: synthetic peptide corresponding to human IRAK-1 amino acids 700-712
Host: rabbit
Cross Reactivity: (+) human and mouse IRAK-1; (−) IRAK-2
Application(s): IP and WB
IRAK-1 is associated with the IL-1 receptor subunits IL-1RI and IL-1RAcP after IL-1 binding and serves as a signaling molecule to mediate IL-1 response. It mediates a signaling cascade leading to NF-κB activation by members of the IL-1 family including IL-1 and IL-18.