Synonyms: 2-[2-Methoxy-4-[(4-oxo-2-thioxo-5-thiazolidinylidene)methyl]phenoxy]-acetic acid ethyl ester; Inhibitor of Mastermind Recruitment-1
Molecular Formula: C15H15NO5S2
Molecular Weight: 353.41
Linear Structural Formula: C15H15NO5S2
Purity: >=98% (HPLC)
Storage: 2-8C
Biochem Physiol Actions: IMR-1 is a cell penetrant and potent inhibitor of Notch transcriptional activation complex that disrupted the recruitment of Mastermind-like 1 (Maml1) to the Notch transcriptional activation complex on chromatin. IMR-1 potently inhibits the growth of Notch-dependent cancer cell lines, and inhibits growth of patient-derived tumor xenografts. IMR-1 is hydrolyzed in vivo to acid metabolite IMR-1A.