Synonyms: (E)-4-(5-(Methoxycarbonyl)-2,2'-bithiophen-4-ylamino)-4-oxobut-2-enoic acid; 4-[(3-Carboxy-1-oxo-2-propenyl)amino]-[2,2'-bithiophene]-5-carboxylic acid 5-methyl ester; 4-{[2-(Methoxycarbonyl)-5-(2-thienyl)-3-thienyl]amino}-4-oxo-2-butenoic acid; HTS 01037; HTS-01037
Molecular Formula: C14H11NO5S2
Molecular Weight: 337.37
Linear Structural Formula: C14H11NO5S2
MDL Number: MFCD02681826
Purity: >=98% (HPLC)
Storage: -20C
Biochem Physiol Actions: HTS01037 is a selective, high-affinity fatty acid-binding protein FABP4 (AFABP; aP2) antagonist (aP2 Ki = 0.67 muM; EFABP/HF/IFABP/LFABP Ki = 3.40/9.07/6.57/8.17 muM) that targets aP2 long-chain fatty acid-binding site. HTS01037 is shown to downregulate basal and fatty acid-stimulated LTC4 levels in primary murine peritoneal macrophages (0.2-20 muM), upregulate murine macrophage RAW 264.7 intracellular free fatty acids and uncoupling protein 2 (UCP2) mRNA levels (30 muM), as well as suppress PPARgamma target genes expression in IL-4 polarized human primary macrophages (10-25 muM).