Antigen: human hepsin amino acids 241-260
Host: rabbit
Cross Reactivity: (+) human hepsin; other species produce bands of unknown identity
Application(s): IHC (formalin-fixed paraffin-embedded tissue) and WB
Hepsin is a type II membrane-associated protein that has an extracellular proteolytic domain and exhibits low sequence homology to other known proteases. Hepsin overexpression is observed in prostate, breast, kidney, and ovarian cancers and due to low homology to other known proteases may provide a unique target for pharmacological therapy. Hepsin is necessary for cell growth in vitro and may play a role in metastatic expansion by factor VII activation.