Synonyms: INH; Isonicotinic acid hydrazide; Isonicotinic hydrazide
Formula: C6H7N3O
Formula Weight: 137.14
CAS No.: 54-85-3
Purity: ≥99% (TLC)
Biochem/physiol Actions: Antibiotic for treatment of Mycobacterium tuberculosis, inhibits mycolic acid biosynthesis. Metabolized by hepatic N-acetyltransferase (NAT) and cytochrome P450 2E1 (CYP2E1) to form hepatotoxins. Selectively induces expression of CYP2E1. Reversibly inhibits CYP2C19 and CYP3A4 activities, and mechanistically inactivates CYP1A2, CYP2A6, CYP2C19 and CYP3A4 at clinically relevant concentrations.
Packaging: 5, 50, 250 g in poly bottle
Assay: ≥99% (TLC)
Fluorescence: λex 360 nm; λem 450 nm (thiol adduct)
MP: 171-173°C(lit.)