CHAPS (3-(3-Cholamidopropyl)dimethylammonio)-1-propanesulfonate)

Type: Zwitterionic detergent Full Name: 3-[(3-Cholamidopropyl)dimethylammonio]-1-propanesulfonate Mol. Formula: C32H58N2O7S Mol Weight: 614.9

Form: White solid

Purity: >99%
Solubility: Water soluble

Conductivity: <25µS in a 10% solution

Critical micelle concentration (CMC): 6-10mM (25°C)

Aggregation number: 10

Cloud point: >100°C
Average micellar weight: 6150

Features

• Zwitterionic detergent
• Non-denaturing
• Electrically neutral

Applications

• Has all the advantages of sulfobetaine containing detergents: hydrophobic, bile salt, and anionic detergents in a single molecule.
• Better at solubilizing proteins and breaking protein-protein interactions.
• Less protein aggregation than non-ionic detergents.
• Capable of solubilizing opiate receptors.
• CHAPS can be removed from protein solutions with a detergent removing gel or by dialysis.