Synonyms: (+)-Brusatol; (11beta,12alpha,15beta)-13,20-Epoxy-3,11,12-trihydroxy-15-[(3-methyl-1-oxo-2-buten-1-yl)oxy]-2,16-dioxo-picras-3-en-21-oic acid methyl ester; Brutasol; NSC 172924; Yatansin
Molecular Formula: C26H32O11
Molecular Weight: 520.53
Linear Structural Formula: C26H32O11
MDL Number: MFCD23726642
Purity: >=95% (HPLC)
Storage: -20C
Application: Brusatol has been used to study the protective role of Nrf2 (nuclear factor, erythroid 2 like 2 ) in intestinal ischemia/reperfusion induced injury.
Biochem Physiol Actions: Brusatol promotes Nrf2 (nuclear factor, erythroid 2 like 2 ) ubiquitination and degradation. Brusatol upregulates the expression of multiple ribosomal components and controls macromolecular complex function.