BMH-21 is a planar heterocyclic small molecule DNA intercalator.
Synonyms: N-[2-(Dimethylamino)ethyl]-12-oxo-2H-benzo[g]pyrido[2,1-b]quinazoline-4-carboxamide
Molecular Formula: C21H20N4O2
Molecular Weight: 360.41
Linear Structural Formula: C21H20N4O2
MDL Number: MFCD27225377
Purity: >=98% (HPLC)
Storage: 2-8C
Application: BMH-21 has been used in cell culture.
Biochem Physiol Actions: BMH-21 is a potent inhibitor of RNA Pol I. BMH-21 binds strongly to GC-rich DNA sequences, ultimately inhibiting RNA Pol I, blocking transcription and disrupting the nucleolar structure. BMH-1 causes dissociation of the RPA194 catalytic subunit from Pol I, and disassembly of Pol I:DNA complexes. The compound BMH-21 inhibits proliferation of a broad range of tumor cell lines.