Synonyms: Anti-Protein WAVE-1 antibody produced in rabbit; Anti-Verprolin homology domain-containing protein 1 antibody produced in rabbit; Anti-WASP-family protein member 1 antibody produced in rabbit; Anti-Wiskott-Aldrich syndrome protein family member 1 antibody produced in rabbit
MDL Number: MFCD04118689
Storage: -20C
Application: All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org)and as a result, are supported by the most extensive characterization in the industry. The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.
Biochem Physiol Actions: Wiskott-Aldrich syndrome protein family member 1 is a protein encoded by the WASF1 gene in humans. It is referred as WAVE, SCAR1 and WAVE1. It plays a critical role downstream of Rac in regulating the actin cytoskeleton required for membrane ruffling. It is implicated in cancer cell migration and invasion. It may promote the proliferative and invasive malignant behaviors through the activation of the PI3K/AKT and p38MAPK signaling pathways in epithelial ovarian cancer (EOC). It acts as an novel and crucial predictor for EOC metastasis.
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