The TOX high mobility group box family member 3 (TOX3) gene with seven exons, is mapped to human chromosome 16q12. The encoded protein is mainly expressed in brain and breast. TOX3 includes a high mobility group box (HMG-box) domain and a C- terminal polyglutamine stretch.
Synonyms: Anti-Cagf9; Anti-Tnrc9; Anti-Tox high mobility group box family member 3
Storage: -20C
Application: Anti-TOX3 antibody produced in rabbit has been used in immunohistochemistry.
Biochem Physiol Actions: TOX high mobility group box family member 3 (TOX3) interacts with cAMP response element (CRE)-binding protein (CREB) and CREB-binding protein (CBP) and regulates calcium-dependent transcription in neurons. Overexpression or mutation of the gene is associated with the development and progression of breast cancer.
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