Serine and arginine rich splicing factor 5 (SRSF5) is encoded by the gene mapped to human chromosome 14. The encoded protein belongs to the SR protein family and is ubiquitously expressed.
Synonyms: Anti-Hrs; Anti-Serine/arginine-rich splicing factor 5; Anti-Sfrs5; Anti-Srp40
Storage: -20C
Application: Anti-SRSF5 antibody produced in rabbit has been used in immunoblotting (1:1000 dilution).
Biochem Physiol Actions: Serine and arginine rich splicing factor 5 (SRSF5) is a major splicing regulator of human immunodeficiency virus type 1 (HIV-1) mRNA. It functions as a potential diagnostic marker for small-cell lung cancer and pleural metastatic cancer. Increased expression of SRSF5 boosts lamin A mRNA production in HeLa cells and fibroblasts of patients with hutchinson gilford progeria syndrome (HGPS), which is a rare genetic disease leading to accelerated aging. Thus, this protein acts as a potential therapeutic perspective for premature aging.
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