Speckled protein of 100 kDa (Sp100), an interferon (IFN)-inducible acidic protein is considered as a component of the ND10 nuclear body. Sp100A, Sp100B, Sp100C and Sp100HMG are the four unique isoforms, expressed by human. Sp100 gene is mapped to human chromosome 2q37.
Synonyms: SP100 Antibody - Anti-SP100 antibody produced in rabbit; Sp100 Antibody; Anti-Lysp100b; Anti-Nuclear autoantigen Sp-100; Anti-Nuclear dot-associated Sp100 protein; Anti-Speckled 100 kDa
Storage: -20C
Application: All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org)and as a result, are supported by the most extensive characterization in the industry. The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.
Biochem Physiol Actions: Speckled protein of 100 kDa (Sp100) possesses transcription-activating and repressive properties. In human papillomavirus (HPV) lifecycle, Sp100 serves as a host restriction factor at early and late times. It is capable of suppressing transcription and replication of the DNA of HPV during the onset of infection.
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