Secretory leukocyte peptidase inhibitor (SLPI) is a serine-protease inhibitor which belongs to whey acidic protein family. The gene is mapped to human chromosome 20q13.12. It has four exons and encodes protein of molecular weight 11.7 kDa. It has whey-acidic-protein (WAP) motifs and the cysteine disulfide bond is crucial for its compact structure. It is secreted by epithelial cells and is present in saliva, cervical mucus and in seminal fluid.
Synonyms: Anti-ALK1; Anti-ALP; Anti-BLPI; Anti-HUSI; Anti-HUSI-I; Anti-WAP4; Anti-WFDC4; Anti-secretory leukocyte peptidase inhibitor
MDL Number: MFCD03839167
Storage: -20C
Application: All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org)and as a result, are supported by the most extensive characterization in the industry. The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.
Biochem Physiol Actions: Secretory leukocyte peptidase inhibitor (SLPI) functions to protect tissues during inflammation. It inhibits human immunodeficiency virus 1 (HIV-1) infection by interacting with and modulating cluster of differentiation (CD4) lymphocytes. SLPI has antimicrobial property and regulates wound healing. It also interacts with ß1 tubulin in platelets and regulates proteolysis. SLPI promotes carcinogenesis in lung cancer. Low expression of SLPI in nasopharyngeal epithelium promotes Epstein-Barr virus (EBV)-mediated nasopharyngeal carcinoma (NPC). SLPI is highly expressed in ovarian and pancreatic cancer.
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