The Shiga toxins are a family of related protein toxins secreted by certain types of bacteria. Shiga toxin (Stx) is produced by Shigella dysenteriae; whereas, the Shiga-like toxins, Stx1 and Stx2, with a few known isoforms, are secreted by specific strains of Escherichia coli named Shiga-toxin-producing E. coli (STEC) such as E. coli O157:H7. The latter may cause bloody diarrhea and hemorrhagic colitis in humans, which may lead to fatal systemic complications.
Synonyms: Anti-SLT-1 B subunit; Anti-SLT-1b; Anti-Shiga-like toxin 1 subunit B; Anti-Verocytotoxin 1 subunit B; Anti-Verotoxin 1 subunit B; Anti-stxB
Storage: -20C
Application: Anti-Shiga Toxin 1, B Subunit (STxB) antibody, Mouse monoclonal has been used in:
•immunoblotting
• flow cytometry
• immunoprecipitation
Biochem Physiol Actions: Shiga-toxin (Stx) produced by E. coli O157:H7 may cause bloody diarrhea and hemorrhagic colitis in humans, which may lead to fatal systemic complications. All the Stx isoforms have similar structure and mechanism of action. The catalytic A subunit has RNA N-glycosidase activity that inhibits eukaryotic protein synthesis. The B subunits form a pentamer, which recognizes and binds to the functional cell-surface receptor globotriaosylceramide [Gb3, Gala(1-4)-Galb (1-4)-Glcb1-ceramide]. Gb3 is overexpressed in membranes of numerous tumor cells, Therefore, STxB binding to Gb3 receptors may be useful for cell-specific vectorization, labeling, and imaging purposes.
Other Notes: This product is for R&D use only, not for drug, household, or other uses.