SCN4B (Sodium channel, voltage-gated, type IV, ß subunit) is a 250kDa voltage-gated sodium (Nav) channel of the Nav channel signaling complex. It consists of a cleaved signal sequence, an extracellular Ig-like fold, a transmembrane segment, and a short intracellular C-terminal tail. It is expressed in neurons in the brain, spinal cord, and some sensory neurons.
Synonyms: Anti-LQT10
Storage: -20C
Application: All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org)and as a result, are supported by the most extensive characterization in the industry. The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.
Biochem Physiol Actions: SCN4B (Sodium channel, voltage-gated, type IV, ß subunit) plays a key role in cellular communication. It influences the transmembrane voltage gradient for proper transmission of cellular messages over long distances. It is a multifunctional single-transmembrane glycoprotein associated with several sodium channel activities such as maintenance of the gating properties of voltage-gated ion channels, regulation of Nav channel trafficking as well as its expression levels and facilitating cell adhesion and migration. It also plays an important role in the protein-protein interactions. Mutation in SCN4B causes familial atrial fibrillation and congenital long-QT syndrome.
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