RNA polymerase II (Pol II) is a multi-subunit enzyme responsible for the transcription of protein-coding genes. Transcription initiation requires recruitment of the complete transcription machinery to a promoter via solicitation by activators and chromatin remodeling factors. Pol II can coordinate 10 to 14 subunits. This complex interacts with the promoter regions of genes and a variety of elements and transcription factors. The DNA binding domain of the polymerase is a groove where TFIIB orients the DNA for unwinding and transcription.
Application: Research Sub CategoryTranscription Factors
Legal Information: UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
Other Notes: Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.